Clinical trialNCT06205485RecruitingPhase 3Interventional

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

SponsorCanadian Cancer Trials GroupEnrollment250Rectal Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is being done to answer the following questions: Is the chance of rectal cancer responding the same if chemotherapy alone is given before limited surgery compared to chemotherapy and radiation therapy given together before limited surgery? If radiation therapy is not given, is quality of life better?

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Carl Brown
St. Paul's Hospital, Vancouver, BC, Canada
Study Chair
clinicaltrials.gov ↗
Hagen Kennecke
Providence Portland Medical Centre, Portland, OR, USA
Study ChairKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

113 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Bcca-Vancouver Cancer Centre
Vancouver, British Columbia, Canada
Jonathan M. Loree
Recruiting
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Eric Hyun
Recruiting
Doctor H. Bliss Murphy Cancer Centre
St. John's, Newfoundland and Labrador, Canada
Teri L. Stuckless
Recruiting
London Regional Cancer Program
London, Ontario, Canada
Terry M. Zwiep
Recruiting
Ottawa Hospital and Cancer Center-General Campus
Ottawa, Ontario, Canada
Kristopher Dennis
Recruiting
Ciusssemtl-Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Mikael Soucisse
Recruiting
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada
Mussawar Iqbal
Recruiting
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
Shahid Ahmed
Recruiting

United States

Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Shahzad Siddique
Recruiting
Uci Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
Jason A. Zell
Recruiting
Los Angeles General Medical Center
Los Angeles, California, United States
Joshua P. Schiff
Recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Joshua P. Schiff
Recruiting
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
Jason A. Zell
Recruiting
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, United States
Shahzad Siddique
Recruiting
Beebe South Coastal Health Campus
Millville, Delaware, United States
Gregory A. Masters
Recruiting
Helen F Graham Cancer Center
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Medical Oncology Hematology Consultants Pa
Newark, Delaware, United States
Gregory A. Masters
Recruiting
Beebe Health Campus
Rehoboth Beach, Delaware, United States
Gregory A. Masters
Recruiting
Orlando Health Cancer Institute
Orlando, Florida, United States
Suspended
Emory Saint Joseph'S Hospital
Atlanta, Georgia, United States
Patrick S. Sullivan
Recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
Patrick S. Sullivan
Recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Patrick S. Sullivan
Recruiting
Rush-Copley Medical Center
Aurora, Illinois, United States
Prem Sobti
Recruiting
Northwestern University
Chicago, Illinois, United States
Aparna Kalyan
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Prem Sobti
Recruiting
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Aparna Kalyan
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Prem Sobti
Recruiting
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Aparna Kalyan
Recruiting
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Prem Sobti
Recruiting
Carle Cancer Center
Urbana, Illinois, United States
Prem Sobti
Recruiting
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States
Aparna Kalyan
Recruiting
Northwest Cancer Center - Crown Point
Crown Point, Indiana, United States
Prem Sobti
Recruiting
Northwest Oncology Llc
Dyer, Indiana, United States
Prem Sobti
Recruiting
Northwest Cancer Center - Hobart
Hobart, Indiana, United States
Prem Sobti
Recruiting
Saint Mary Medical Center
Hobart, Indiana, United States
Prem Sobti
Recruiting
the Community Hospital
Munster, Indiana, United States
Prem Sobti
Recruiting
Northwest Cancer Center - Valparaiso
Valparaiso, Indiana, United States
Prem Sobti
Recruiting
Ochsner Hematology Oncology North Shore - Covington (west Region)
Covington, Louisiana, United States
Jonathan D. Mizrahi
Recruiting
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States
Jonathan D. Mizrahi
Recruiting
University Medical Center New Orleans
New Orleans, Louisiana, United States
Sanda A. Tan
Recruiting

73 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Capecitabine →FluoruracilLeucovorin →Oxaliplatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 26 Jun 2024
Primary completion: 30 Jan 2030
Completion: 30 Jun 2030
Last update posted: 14 Jul 2026
Registered enrollment: 250
Registry id: NCT06205485

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.