Clinical trialNCT06213649RecruitingPhase 3Interventional

Parasitic Ulcer Treatment Trial

SponsorJeremy Keenan, MD, MPHEnrollment232Acanthamoeba Keratitis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis (AK) will improve vision. Patients presenting to all enrollment centers with evidence of acanthamoeba keratitis will be eligible for the trial if there is evidence of ocular inflammation after 4 weeks of anti-amoebic therapy. Those who agree to participate will be randomized to one of two treatment groups: * Group 1: Topical corticosteroid * Group 2: Topical placebo

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Gerami Seitzman, MD
Proctor Foundation, UCSF
Principal Investigator
clinicaltrials.gov ↗
Jeremy Keenan, MD, MPH
Proctor Foundation, UCSF
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

17 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Brazil

Federal University of São Paulo
São Paulo, Brazil
Recruiting

India

Aravind Eye Hospital
Coimbatore, Tamil Nadu, India
Recruiting
Aravind Eye Hospital
Madurai, Tamil Nadu, India
Recruiting

United Kingdom

Moorfields Eye Hospital
London, United Kingdom
Recruiting

United States

University of California, San Francisco
San Francisco, California, United States
Gerami Seitzman, MDJeremy Keenan, MD, MPH →
Recruiting
University of Colorado Anschutz
Aurora, Colorado, United States
Recruiting
University of Florida
Gainesville, Florida, United States
Recruiting
University of Miami
Miami, Florida, United States
Recruiting
University of Illinois, Chicago
Chicago, Illinois, United States
Recruiting
University of Iowa
Iowa City, Iowa, United States
Recruiting
Johns Hopkins University
Baltimore, Maryland, United States
Recruiting
Columbia University
New York, New York, United States
Recruiting
Oregon Health and Science University
Portland, Oregon, United States
Recruiting
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Recruiting
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
Recruiting
Baylor College of Medicine
Houston, Texas, United States
Recruiting
University of Washington
Seattle, Washington, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PolihexanideTopical corticosteroid

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Jul 2024
Primary completion: 31 Jul 2029
Completion: 31 Jul 2029
Last update posted: 1 May 2026
Registered enrollment: 232
Registry id: NCT06213649

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.