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Clinical trialNCT06230887Enrolling, by, invitationInterventional

Implementation of Innovative Treatment for Moral Injury Syndrome: A Hybrid Type 2 Study

SponsorVA Office of Research and DevelopmentEnrollment200Moral Injury Syndrome
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Moral Injury Syndrome (MIS) affects up to 35-60% of Veterans managing combat-related PTSD; it results from experiences that challenge deeply held values or spiritual beliefs. Symptoms of MIS may include hopelessness, helplessness, loss of spiritual beliefs, difficulty with forgiveness, loss of meaning or purpose, reduced trust in self or others, or intractable guilt, shame or anger. Veterans managing MIS have difficulty responding to mental health treatment, and are at increased risk for suicide ideation or attempts. To date evidence-based interventions for MIS are not widely available in VA. This study will implement an evidence-based intervention for MIS in four VA facilities, collect data on the effectiveness of the intervention, and develop an implementation toolkit. This data will inform national dissemination in collaboration with the Office of Mental Health and Suicide Prevention and the National Chaplain Service.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Jeffrey M Pyne, MD

    Central Arkansas Veterans Healthcare System , Little Rock, AR

    Principal Investigator

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Central Arkansas Veterans Healthcare System , Little Rock, Ar

    Little Rock, Arkansas, United States

  • Atlanta Va Medical and Rehab Center, Decatur, Ga

    Decatur, Georgia, United States

  • Maine Va Medical Center, Augusta, Me

    Augusta, Maine, United States

  • Minneapolis Va Health Care System, Minneapolis, Mn

    Minneapolis, Minnesota, United States

  • Michael E. Debakey Va Medical Center, Houston, Tx

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Jul 2024
Primary completion
1 Jan 2028
Completion
31 Jul 2028
Last update posted
20 Jul 2026
Registered enrollment
200
Registry id
NCT06230887

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.