Clinical trialNCT06238778CompletedPhase 2Interventional

Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec

SponsorDiasome PharmaceuticalsEnrollment227Diabetes Mellitus, Type 1

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this study is to see if directing insulin to the liver will improve the low blood sugar that sometimes happens when injecting insulin in Type 1 diabetes patients. Participants will use continuous glucose monitoring to measure the sugar levels in their blood, and work with the doctor to find the best doses. One group of patients will get the liver targeting insulin, and the other group will use insulin they normally use for treating Type 1 diabetes. The participant will be part of the study for up to 32 weeks.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Ruth Weinstock, MD
State University of New York - Upstate Medical University
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

27 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Marvel Clinical Research
Huntington Beach, California, United States
Pasadena Clinical Trials
Pasadena, California, United States
Diabetes Research Center
Tustin, California, United States
University of Colorado, Barbara Davis Center
Denver, Colorado, United States
East Coast Institute for Research
Jacksonville, Florida, United States
University of Miami Diabetes Research Institute
Miami, Florida, United States
Metabolic Research Institute
West Palm Beach, Florida, United States
Atlanta Diabetes Associates
Atlanta, Georgia, United States
East Coast Institute for Research
Canton, Georgia, United States
Physicians Research Associates, Llc
Lawrenceville, Georgia, United States
Endocrine Research Solutions, Inc.
Roswell, Georgia, United States
University of Chicago Kovler Diabetes Center
Chicago, Illinois, United States
Endeavor Health
Skokie, Illinois, United States
Indiana Medical Research Institute
Merrillville, Indiana, United States
Suny Upstate Medical University
Syracuse, New York, United States
Asheville Clinical Research
Asheville, North Carolina, United States
Unc Endo Clinical Research Unit
Chapel Hill, North Carolina, United States
Physician'S East
Greenville, North Carolina, United States
University Hospitals Medical Center
Cleveland, Ohio, United States
Texas Diabetes & Endocrinology
Austin, Texas, United States
Tekton Research, Llc
Irving, Texas, United States
Tekton Research, Llc
McKinney, Texas, United States
Texas Diabetes % Endocrinology
Round Rock, Texas, United States
Clinical Trials of Texas
San Antonio, Texas, United States
Tekton Research, Llc
San Antonio, Texas, United States
Wasatch Clinical Research, Llc 310
Salt Lake City, Utah, United States
Virginia Endocrinology Research
Chesapeake, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

HDV-LisproLispro

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 Dec 2023
Primary completion: 27 Oct 2025
Completion: 16 Dec 2025
Last update posted: 31 Jul 2026
Registered enrollment: 227
Registry id: NCT06238778

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.