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Clinical trialNCT06258525Not, yet, recruitingPhase 2Interventional

SAMe in Prevention of Oxaliplatin-associated Liver Injury

SponsorCedars-Sinai Medical CenterEnrollment305-Fluorouracil ToxicityColorectal CancerLiver InjuryLiver MetastasesLiver Metastasis Colon CancerLiver Toxicity, Chemically-Induced+1 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an open-label, phase II study that may provide evidence that taking S-adenosylmethionine (SAMe) supplementation prevents oxaliplatin, a type of chemotherapy drug, associated liver toxicity in patients with resectable colorectal liver metastases. Resectable means that it is able to removed with surgery. Patients will take two SAMe tablets in the morning and one tablet in the evening for 3-6 months (about 6-8 cycles of chemotherapy) in addition to oxaliplatin based chemotherapy followed by surgical removal of the colorectal liver metastases.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Cedars-Sinai Medical Center Beverly Hills

    Los Angeles, California, United States

    Alexandra Gangi, MDJeremy Lorber, MDKevin S. Scher, MD
  • Cedars-Sinai Medical Center at Socc

    Los Angeles, California, United States

    Alexandra Gangi, MDAndrew Hendifar, MDArsen Osipov, MDJun Gong, MDMaha Guindi, MD

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jul 2026
Primary completion
31 Aug 2028
Completion
31 Aug 2028
Last update posted
6 May 2026
Registered enrollment
30
Registry id
NCT06258525
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.