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Clinical trialNCT06282874Active, not recruitingPhase 4Interventional

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

SponsorGuangdong Association of Clinical TrialsEnrollment41Brain MetastasesCarcinoma, Non-Small-Cell LungLeptomeningeal Metastasis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is an investigator-initiated, prospective, open-label, single-arm, multicenter clinical trial aimed at exploring the antitumor activity of Lorlatinib in ALK-positive NSCLC patients with brain/ leptomeningeal metastases.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

China
  • Tenth Affiliated Hospital, Southern Medical University (dongguan People'S Hospital)

    Dongguan, Guangdong, China

  • the First People'S Hospital of Foshan

    Foshan, Guangdong, China

  • Guangdong Provincial Perople'S Hospital

    Guangzhou, Guangdong, China

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Lorlatinib →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Aug 2024
Primary completion
30 Apr 2026
Completion
1 Mar 2027
Last update posted
9 Apr 2026
Registered enrollment
41
Registry id
NCT06282874
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.