Clinical trialNCT06287775RecruitingPhase 1/PHASE2Interventional

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

SponsorNational Cancer Institute (NCI)Enrollment45Extensive Stage Lung Small Cell CarcinomaStage IV Lung Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II trial tests the safety, side effects, and best dose of iadademstat when given together with atezolizumab or durvalumab, and studies the effect of the combination in treating patients with small cell lung cancer that has spread outside of the lung in which it began or to other parts of the body (extensive stage) who initially received standard of care chemotherapy and immunotherapy. Iadademstat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as atezolizumab or durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Adding iadademstat to either atezolizumab or durvalumab may be able to stabilize cancer for longer than atezolizumab or durvalumab alone in treating patients with extensive stage small cell lung cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Charles M Rudin
JHU Sidney Kimmel Comprehensive Cancer Center LAO
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

43 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

City of Hope Comprehensive Cancer Center
Duarte, California, United States
Matthew Lee
Recruiting
City of Hope at Irvine Lennar
Irvine, California, United States
Matthew Lee
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Lyudmila A. Bazhenova
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Surbhi Singhal
Recruiting
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, United States
Suspended
Yale University
New Haven, Connecticut, United States
Anne C. Chiang
Recruiting
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, United States
Anne C. Chiang
Recruiting
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut, United States
Suspended
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, United States
Anne C. Chiang
Recruiting
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States
Stephen V. Liu
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Aline F. Fares
Recruiting
Moffitt Cancer Center
Tampa, Florida, United States
Suspended
Emory Saint Joseph'S Hospital
Atlanta, Georgia, United States
Ticiana A. Leal
Recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
Ticiana A. Leal
Recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Ticiana A. Leal
Recruiting
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Noura Choudhury
Recruiting
Uc Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, United States
Noura Choudhury
Recruiting
University of Chicago Medicine-Orland Park
Orland Park, Illinois, United States
Noura Choudhury
Recruiting
Uchicago Medicine Northwest Indiana
Crown Point, Indiana, United States
Noura Choudhury
Recruiting
University of Kansas Clinical Research Center
Fairway, Kansas, United States
Chao H. Huang
Recruiting
University of Kansas Cancer Center
Kansas City, Kansas, United States
Chao H. Huang
Recruiting
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, United States
Chao H. Huang
Recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States
Chao H. Huang
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
Zhonglin Hao
Recruiting
Johns Hopkins University/sidney Kimmel Cancer Center
Baltimore, Maryland, United States
Christine L. Hann
Recruiting
University of Maryland/greenebaum Cancer Center
Baltimore, Maryland, United States
Samuel Rosner
Recruiting
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States
Charles M. Rudin
Recruiting
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States
Charles M. Rudin
Recruiting
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States
Charles M. Rudin
Recruiting
Memorial Sloan Kettering Commack
Commack, New York, United States
Charles M. Rudin
Recruiting
Memorial Sloan Kettering Westchester
Harrison, New York, United States
Charles M. Rudin
Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Charles M. Rudin
Recruiting
Memorial Sloan Kettering Nassau
Uniondale, New York, United States
Charles M. Rudin
Recruiting
Carolinas Medical Center/levine Cancer Institute
Charlotte, North Carolina, United States
Christopher R. Pallas
Recruiting
Atrium Health Cabarrus/lci-Concord
Concord, North Carolina, United States
Christopher R. Pallas
Recruiting
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Jimmy Ruiz
Recruiting
University of Cincinnati Cancer Center-Uc Medical Center
Cincinnati, Ohio, United States
Jennifer Leddon
Recruiting
Case Western Reserve University
Cleveland, Ohio, United States
Afshin Dowlati →
Recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Asrar AlAhmadi
Recruiting
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, United States
Jennifer Leddon
Recruiting

3 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Atezolizumab →Durvalumab →Iadademstat

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Apr 2025
Primary completion: 25 Jul 2029
Completion: 25 Jul 2029
Last update posted: 6 Aug 2026
Registered enrollment: 45
Registry id: NCT06287775

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.