Clinical trialNCT06319027RecruitingPhase 2Interventional

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

SponsorECOG-ACRIN Cancer Research GroupEnrollment100Glioblastoma, IDH-Wildtype

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies whether different imaging techniques can provide additional and more accurate information than the usual approach for assessing the activity of tumors in patients with newly diagnosed glioblastoma. The usual approach for this currently is magnetic resonance imaging (MRI). This study is trying to learn more about the meaning of changes in MRI scans after treatment, as while the appearance of some of these changes may reflect progressing tumor, some may be due the treatment. Dynamic susceptibility contrast (DSC)-MRIs, along with positron emission tomography (PET) and/or magnetic resonance (MR) spectroscopy, may help doctors tell which changes are a reflection of the treatment and which changes may be due to progressing tumor.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Daniel P Barboriak
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Jonathan E. McConathy
Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, United States
Jeremy D. Rudnick
Recruiting
Baptist Md Anderson Cancer Center
Jacksonville, Florida, United States
Robert Cavaliere
Recruiting
Moffitt Cancer Center
Tampa, Florida, United States
Joaquim Farinhas
Recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Hui-Kuo G. Shu
Recruiting
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States
Michelle M. Kim
Recruiting
Carolinas Medical Center/levine Cancer Institute
Charlotte, North Carolina, United States
Suspended
Duke University Medical Center
Durham, North Carolina, United States
Annick Desjardins
Recruiting
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Marc Benayoun
Recruiting
Rhode Island Hospital
Providence, Rhode Island, United States
Suspended
Edwards Comprehensive Cancer Center
Huntington, West Virginia, United States
Toni O. Pacioles
Recruiting
West Virginia University Healthcare
Morgantown, West Virginia, United States
Sonikpreet Aulakh
Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin, United States
Michael Veronesi
Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States
Michael Veronesi
Recruiting
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, United States
Jennifer M. Connelly
Recruiting
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Jennifer M. Connelly
Recruiting
Drexel Town Square Health Center
Oak Creek, Wisconsin, United States
Jennifer M. Connelly
Recruiting
Froedtert West Bend Hospital/kraemer Cancer Center
West Bend, Wisconsin, United States
Jennifer M. Connelly
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Gadolinium-Chelate

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 11 Apr 2024
Primary completion: 31 May 2027
Completion: 31 May 2027
Last update posted: 18 Aug 2026
Registered enrollment: 100
Registry id: NCT06319027

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.