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Clinical trialNCT06319248RecruitingPhase 2Interventional

MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

SponsorMayo ClinicEnrollment308Low Blood PressureSepsis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is being done to determine if early administration of Midodrine can improve outcomes by maintaining a higher mean blood pressure off of intravenous medications. Researchers want to see if Midodrine can help people with sepsis need fewer vasopressors, which could mean shorter hospital stays, less time with uncomfortable tubes, and a smoother recovery overall.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Mayo Clinic Arizona

    Scottsdale, Arizona, United States

    Rodrigo Cartin-Ceba, MD
    Recruiting
  • Mayo Clinic Florida

    Jacksonville, Florida, United States

    Devang K. Sanghavi, MBBS, MD
    Recruiting
  • Mayo Clinic Health System - Mankato

    Mankato, Minnesota, United States

    Amos Lal, MBBS
    Recruiting
  • Mayo Clinic Minnesota

    Rochester, Minnesota, United States

    Amos Lal, MBBSOgnjen Gajic, MD
    Recruiting
  • Mayo Clinic Health System - Eau Claire

    Eau Claire, Wisconsin, United States

    Juan Pablo Domecq Garces, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Midodrine →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 May 2024
Primary completion
31 Mar 2029
Completion
30 Jun 2029
Last update posted
22 May 2026
Registered enrollment
308
Registry id
NCT06319248
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.