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Clinical trialNCT06319274RecruitingPhase 2Interventional

Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure

SponsorPär JohanssonEnrollment450Acute Respiratory FailureEndothelial DysfunctionPulmonary Infection
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this clinical trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in 450 mechanically ventilated patients with infectious respiratory failure. The study hypothesis is that iloprost may be beneficial as an endothelial rescue treatment as it is anticipated to deactivate the endothelium and restore vascular integrity in patients suffering from respiratory failure caused by endothelial breakdown, ultimately improving survival.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Denmark
  • Dept. of Anaesthesia and Intensive Care, Bispebjerg Hospital

    Copenhagen, Denmark

    Niels E Clausen, MD
    Recruiting
  • Dept. of Intensive Care, Copenhagen University Hospital Herlev

    Herlev, Denmark

    Peter Soee-Jensen, MD
    Recruiting
  • Dept. of Anaesthesia and Intensive Care, Nordsjaelands Hospital

    Hillerød, Denmark

    Morten Bestle, MD
    Recruiting
  • Dept. of Intensive Care, Hvidovre Hospital

    Hvidovre, Denmark

    Klaus T Kristiansen, MD
    Recruiting
  • Department of Anesthesia and Intensive Care Medicine, Zealand University Hospital

    Køge, Denmark

    Lars Peter K Andersen, MD, PhD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

IloprostIsotonic saline
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
15 Apr 2024
Primary completion
30 Sept 2027
Completion
30 Sept 2027
Last update posted
22 Aug 2025
Registered enrollment
450
Registry id
NCT06319274
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.