Clinical trialNCT06323824RecruitingPhase 4Interventional

Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.

SponsorYale UniversityEnrollment600Opioid Use Disorder

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors influencing the implementation of office-based methadone.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

David Fiellin, MD
Yale University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Highland Hospital Bridge Clinic at Alameda Health System
Oakland, California, United States
Monish Ullal, MD
Recruiting
Outpatient Buprenorphine Induction Clinic, University of California, San Francisco
San Francisco, California, United States
Andy Tompkins, MDChristine Soran, MDPaula Lum, MD
Recruiting
Rapid Start Clinic, Kaiser Permanente Colorado
Denver, Colorado, United States
Ingrid Binswanger, MD
Recruiting
Officed Based Addiction Treatment Program, Boston Medical Center
Boston, Massachusetts, United States
Zoe Weinstein, MD
Recruiting
Hennepin Healthcare Addiction Medicine
Minneapolis, Minnesota, United States
Gavin Bart, MD
Recruiting
Marshall University Division of Addiction Sciences P.R.O.A.C.T
Huntington, West Virginia, United States
Todd Davies, PhDZachary Hansen, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Buprenorphine →Methadone →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 4 Jun 2024
Primary completion: 31 Dec 2028
Completion: 31 Dec 2028
Last update posted: 14 Sept 2026
Registered enrollment: 600
Registry id: NCT06323824

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.