Clinical trialNCT06325202RecruitingInterventional

Closed Loop and Education for Hypoglycemia Awareness Restoration

SponsorMilton S. Hershey Medical CenterEnrollment324Diabetes Mellitus, Type 1

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the CLEAR study is to determine the effect on counterregulatory responses (CRR) of intervening (by attempting to strictly avoid hypoglycemia) to improve awareness of hypoglycemic symptoms among adults with type 1 diabetes (T1D) who have impaired awareness of hypoglycemia (IAH). IAH affects 20-25% of adults with T1D, and rises with increasing duration of T1D.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Elizabeth R Seaquist, MD
University of Minnesota
Study ChairKOL profile →
clinicaltrials.gov ↗
Simon Heller, MD
University of Sheffield
Study Chair
clinicaltrials.gov ↗
Vernon M Chinchilli, PhD
Penn State College of Medicine
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

University of Melbourne
Fitzroy, Victoria, Australia
David O'Neal, MD
Recruiting

United Kingdom

University of Leicester
Leicester, United Kingdom
Pratik Choudhary, MBBS
Recruiting
University of Sheffield
Sheffield, United Kingdom
Simon Heller, MD
Recruiting

United States

University of California, San Diego
La Jolla, California, United States
Jeremy H Pettus, MD
Recruiting
Adventhealth
Orlando, Florida, United States
Anna Casu, MDRichard E Pratley, MD
Recruiting
University of Kentucky
Lexington, Kentucky, United States
Simon Fisher, MD, PhD
Recruiting
University of Minnesota
Minneapolis, Minnesota, United States
Elizabeth R Seaquist, MD →
Recruiting
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Michael R Rickels, MD, MS
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Oct 2025
Primary completion: 31 Jul 2029
Completion: 31 Jul 2029
Last update posted: 3 Mar 2026
Registered enrollment: 324
Registry id: NCT06325202

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.