Clinical trialNCT06368817RecruitingPhase 2Interventional

A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

SponsorChildren's Oncology GroupEnrollment240Basal Ganglia GerminomaDiabetes InsipidusGerminomaPineal Region GerminomaSuprasellar GerminomaThalamic Germinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies how well lower dose radiotherapy after chemotherapy (Carboplatin \& Etoposide) works in treating children with central nervous system (CNS) germinomas. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Researchers want to see if lowering the dose of standard radiotherapy (RT) after chemotherapy can help get rid of CNS germinomas with fewer long-term side effects.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Mohamed S Abdelbaki
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

114 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

John Hunter Children'S Hospital
Hunter Regional Mail Centre, New South Wales, Australia
Suspended
Sydney Children'S Hospital
Randwick, New South Wales, Australia
David S. Ziegler
Recruiting
the Children'S Hospital at Westmead
Westmead, New South Wales, Australia
Bhavna Padhye
Recruiting
Queensland Children'S Hospital
South Brisbane, Queensland, Australia
Steven A. Foresto
Recruiting
Women'S and Children'S Hospital-Adelaide
North Adelaide, South Australia, Australia
Maria L. Kirby
Recruiting
Royal Children'S Hospital
Parkville, Victoria, Australia
Martin A. Campbell
Recruiting
Perth Children'S Hospital
Perth, Western Australia, Australia
Michelle Ng
Recruiting

Canada

University of Alberta Hospital
Edmonton, Alberta, Canada
Sarah J. McKillop
Recruiting
British Columbia Children'S Hospital
Vancouver, British Columbia, Canada
Rebecca J. Deyell
Recruiting
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Stephanie M. Villeneuve
Recruiting
Iwk Health Centre
Halifax, Nova Scotia, Canada
Chelsea Ash
Recruiting
Mcmaster Children'S Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada
Uma H. Athale
Recruiting
Children'S Hospital
London, Ontario, Canada
Shayna M. Zelcer
Recruiting
Hospital for Sick Children
Toronto, Ontario, Canada
Pak Yin Anthony Liu
Recruiting
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
Monia Marzouki
Recruiting
the Montreal Children'S Hospital of the Muhc
Montreal, Quebec, Canada
Stephanie Mourad
Recruiting
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada
Josee Brossard
Recruiting
Chu de Quebec-Centre Hospitalier de L'Universite Laval (chul)
Québec, Canada
Bruno Michon
Recruiting

United States

Usa Health Strada Patient Care Center
Mobile, Alabama, United States
Hamayun Imran
Recruiting
Phoenix Childrens Hospital
Phoenix, Arizona, United States
Michael R. Mangum
Recruiting
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Michael W. Bishop
Recruiting
Loma Linda University Medical Center
Loma Linda, California, United States
Albert Kheradpour
Recruiting
Children'S Hospital Los Angeles
Los Angeles, California, United States
Katrina O'Halloran
Recruiting
Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
Alyssa T. Reddy
Recruiting
Children'S Hospital of Orange County
Orange, California, United States
Elyssa M. Rubin
Recruiting
Lucile Packard Children'S Hospital Stanford University
Palo Alto, California, United States
Jay Michael S. Balagtas
Recruiting
Rady Children'S Hospital - San Diego
San Diego, California, United States
William D. Roberts
Recruiting
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Alyssa T. Reddy
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Holly B. Lindsay
Recruiting
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Michael S. Isakoff
Recruiting
Yale University
New Haven, Connecticut, United States
Farzana Pashankar
Recruiting
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Sridhi Patel
Recruiting
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Jeffrey S. Dome
Recruiting
Memorial Regional Hospital/joe Dimaggio Children'S Hospital
Hollywood, Florida, United States
Iftikhar Hanif
Recruiting
Nemours Children'S Clinic-Jacksonville
Jacksonville, Florida, United States
Sridhi Patel
Recruiting
Nicklaus Children'S Hospital
Miami, Florida, United States
Ziad A. Khatib
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Bradley Gampel
Recruiting
Arnold Palmer Hospital for Children
Orlando, Florida, United States
Jaime M. Libes-Bander
Recruiting
Nemours Children'S Hospital
Orlando, Florida, United States
Sridhi Patel
Recruiting
Nemours Children'S Clinic - Pensacola
Pensacola, Florida, United States
Jeffrey H. Schwartz
Recruiting

74 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Etoposide →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Oct 2024
Primary completion: 4 Nov 2033
Completion: 4 Nov 2033
Last update posted: 16 Jul 2026
Registered enrollment: 240
Registry id: NCT06368817

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.