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Clinical trialNCT06373016RecruitingInterventional

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

SponsorStony Brook UniversityEnrollment100Bipolar DisorderBipolar Disorder Type 1
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood (to assess baseline measures of how the body uses energy), and then to receive two MRI scan sessions, on separate days. During each MRI scan session, participants will play three games, from which they can win money, before and after drinking glucose (on one day) or ketones (on the other day). Investigators will compare individuals with and without bipolar to test whether the two groups differ in how their brains use energy, and to test how the brain's use of energy affects behavior.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Mclean Hospital

    Belmont, Massachusetts, United States

    Dost Ongur, MD PhD
    Recruiting
  • Martinos Center for Biomedical Research, Building 149, 13th Street

    Charlestown, Massachusetts, United States

    Eva-Maria Ratai, PhD
    Recruiting
  • Laufer Center for Physical and Quantitative Biology , Stony Brook University

    Stony Brook, New York, United States

    Active, not recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
26 Jan 2024
Primary completion
1 Feb 2027
Completion
1 Feb 2027
Last update posted
15 Apr 2026
Registered enrollment
100
Registry id
NCT06373016

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.