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Clinical trialNCT06406114RecruitingPhase 2Interventional

Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

SponsorMassachusetts General HospitalEnrollment300Antibiotic AllergyBeta Lactam Adverse ReactionCephalosporin AllergyCephalosporin ReactionDrug AllergyDrug Hypersensitivity+1 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in allergic patients is based on side chain chemical similarity and limited skin testing evidence. This project includes a clinical trial and mechanistic studies to optimize the approach to cephalosporin allergy and advance future diagnostics.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Mayo Clinic Arizona

    Scottsdale, Arizona, United States

    Alexei Gonzalez-Estrada, MD
    Recruiting
  • University of California, San Francisco

    San Francisco, California, United States

    Recruiting
  • Massachusetts General Hospital

    Boston, Massachusetts, United States

    Aleena Banerji, MD
    Recruiting
  • Rochester General Hospital

    Rochester, New York, United States

    Allison C Ramsay, MD
    Recruiting
  • Vanderbilt University Medical Center

    Nashville, Tennessee, United States

    Elizabeth Phillips, MD
    Recruiting
  • University of Texas Southwestern Medical Center

    Dallas, Texas, United States

    Dave Khan, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Amoxicillin double-blind placebo-controlled drug challengeBeta-lactam antibiotic double-blind skin testingCulprit cephalosporin double-blind placebo-controlled drug challengeDissimilar cephalosporin antibiotic double-blind placebo-controlled drug challengeSimilar cephalosporin antibiotic double-blind placebo-controlled drug challenge
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
5 May 2025
Primary completion
1 Jul 2028
Completion
31 Dec 2028
Last update posted
26 May 2026
Registered enrollment
300
Registry id
NCT06406114
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.