Clinical trialNCT06422923RecruitingPhase 1/PHASE2Interventional

A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)

SponsorNeurona TherapeuticsEnrollment10Epilepsy, Temporal Lobe

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multicenter, single arm, open label clinical trial that is designed to test the safety and preliminary efficacy of single administration inhibitory nerve cells called interneurons (NRTX-1001), into both temporal lobes of subjects with drug-resistant bilateral mesial temporal lobe epilepsy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Eduardo Dunayevich, MD
Neurona Therapeutics
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

17 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Sisira Yadala, MD
Recruiting
University of Southern California Keck Hospital
Los Angeles, California, United States
Charles Y Liu, MD, PhD
Recruiting
Uc Irvine Medical Center
Orange, California, United States
Mona Sazgar, MD
Recruiting
Stanford University
Palo Alto, California, United States
Kevin Graber, MD
Recruiting
University of California San Diego
San Diego, California, United States
Jerry J Shih, MD
Recruiting
University of California San Francisco
San Francisco, California, United States
Withdrawn
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Steven Ojemann, MD
Recruiting
University of Chicago
Chicago, Illinois, United States
Peter Warnke, MD
Recruiting
University of Iowa Health Care
Iowa City, Iowa, United States
Mark Granner, MD
Recruiting
Suny Upstate Medical University
Syracuse, New York, United States
Shahram Izadyar, MD
Recruiting
Atrium Health
Charlotte, North Carolina, United States
Rajdeep Singh, MD
Recruiting
Duke University Hospital
Durham, North Carolina, United States
Derek Southwell, MD, PhD
Recruiting
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
Gautam S Popli, MD, MBA
Recruiting
Oregon Health and Science University
Portland, Oregon, United States
David C Spencer, MD
Recruiting
Uthealth Houston
Houston, Texas, United States
Nitin Tandon, MD
Recruiting
Uva Health University Medical Center
Charlottesville, Virginia, United States
Nathan Fountain, MD
Recruiting
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Sean Lew, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

NRTX-1001

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Nov 2024
Primary completion: 15 Jun 2027
Completion: 15 Jun 2042
Last update posted: 7 Jan 2026
Registered enrollment: 10
Registry id: NCT06422923

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.