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Clinical trialNCT06424236TerminatedPhase 2/PHASE3Interventional

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation

SponsorWashington University School of MedicineEnrollment73Alzheimers DiseaseAlzheimers Disease, FamilialDementia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to assess the safety, tolerability, biomarker, cognitive and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive/clinical impairment or improves disease-related biomarkers.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

17 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Neuroscience Research Australia

    Randwick, New South Wales, Australia

  • Mental Health Research Institute

    Melbourne, Victoria, Australia

  • the Mccuster Foundation of Alzheimer'S Disease Research

    Nedlands, Western Australia, Australia

France
  • Chu de Toulouse - Hôpital Purpan

    Toulouse, Haute Garonne, France

  • Groupe Hospitalier Pitie-Salpetriere

    Paris, Paris, France

  • Chu de Rouen - Hôpital Charles Nicolle

    Rouen, Seine Maritime, France

Puerto Rico
  • University of Puerto Rico, School of Medicine

    San Juan, Puerto Rico

Spain
  • Hospital Clínic I Provincial de Barcelona

    Barcelona, Spain

United Kingdom
  • the National Hospital for Neurology and Neurosurgery

    London, Greater London, United Kingdom

United States
  • University of Alabama in Birmingham

    Birmingham, Alabama, United States

  • University of California San Diego Medical Center

    La Jolla, California, United States

  • Emory University

    Atlanta, Georgia, United States

  • Indiana University School of Medicine

    Indianapolis, Indiana, United States

  • Washington University in St. Louis

    St Louis, Missouri, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, United States

  • Butler Hospital

    Providence, Rhode Island, United States

  • University of Washington

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Gantenerumab
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
3 Jun 2020
Primary completion
6 Oct 2023
Completion
13 Nov 2023
Last update posted
4 Feb 2025
Registered enrollment
73
Registry id
NCT06424236

Cross-registrations

EU-CTR / CTIS (EudraCT)2013-000307-17

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.