Clinical trialNCT06466135RecruitingPhase 2Interventional

Study of WAL0921 in Patients With Glomerular Kidney Diseases

SponsorWalden BiosciencesEnrollment96Diabetic NephropathiesMinimal Change DiseasePrimary Focal Segmental GlomerulosclerosisPrimary Immunoglobulin A NephropathyPrimary Membranous Nephropathy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an adaptive prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of WAL0921 in subjects with glomerular kidney disease and proteinuria, including diabetic nephropathy and rare glomerular kidney diseases (primary focal segmental glomerulosclerosis \[FSGS\], treatment-resistant minimal change disease \[TR MCD\], primary immunoglobulin A nephropathy \[IgAN\], and primary membranous nephropathy \[PMN\]). Subjects in this study will be randomized to receive the investigational drug WAL0921 or placebo as an intravenous infusion once every 2 weeks for 7 total infusions. All subjects will be followed for 24 weeks after their last infusion.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Rekha Abichandani, MD
Walden Biosciences
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

50 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Westmead Hospital
Westmead, New South Wales, Australia
Recruiting
Western Health Sunshine Hospital
St Albans, Victoria, Australia
Recruiting

India

Aiims Hospital
Raipur, Chhattisgarh, India
Active, not recruiting
Muljibhai Patel Urological Hospital
Nadiād, Gujarat, India
Active, not recruiting
Dhiraj Hospital
Vadodara, Gujarat, India
Active, not recruiting
Ms Ramaiah Medical College and Hospitals
Bangalore, Karnataka, India
Active, not recruiting
Mazumdar Shah Medical Center
Bangalore, Karnataka, India
Active, not recruiting
Manipal Hospital
Pune, Maharashtra, India
Active, not recruiting
Mgm Medical Care and Hospital
Sambhajinagar, Maharashtra, India
Active, not recruiting
Sir Ganga Ram Hospital
New Delhi, National Capital Territory of Delhi, India
Active, not recruiting
Max Super Speciality Hospital
Patparganj, National Capital Territory of Delhi, India
Active, not recruiting
Sum Hospital
Bhubaneswar, Odisha, India
Active, not recruiting
Sms Medical College and Hospital
Jaipur, Rajasthan, India
Active, not recruiting
Nizam'S Institute of Medical Sciences
Hyderabad, Telangana, India
Active, not recruiting
Osmania General Hospital
Hyderabad, Telangana, India
Active, not recruiting
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, India
Active, not recruiting
Nutema Hospital
Meerut, Uttar Pradesh, India
Active, not recruiting
Shri Guru Ram Rai Institute of Medical and Health Sciences
Dehradun, Uttarakhand, India
Active, not recruiting
Nrs Medical College and Hospital Kolkata
Kolkata, West Bengal, India
Active, not recruiting

Malaysia

Hospital Canselor Tuanku Muhriz Ukm
Cheras, Kuala Lumpur, Malaysia
Recruiting
Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur, Malaysia
Recruiting
University Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, Malaysia
Recruiting
Hospital Tengku Ampuan Afzan
Kuantan, Pahang, Malaysia
Recruiting
Hospital Sultan Idris Shah Serdang
Kajang, Selangor, Malaysia
Recruiting
Sunway Medical Centre
Petaling Jaya, Selangor, Malaysia
Recruiting

South Korea

Hallym University Sacred Heart Hospital
Anyang, South Korea
Recruiting
Pusan National University Hospital
Busan, South Korea
Recruiting
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Recruiting
Severance Hospital - Yonsei Cancer Center
Seoul, South Korea
Recruiting
Samsung Medical Center
Soeul, South Korea
Recruiting
Ajou University Hospital
Suwon, South Korea
Recruiting

Sri Lanka

National Hospital of Sri Lanka
Colombo, Sri Lanka
Not, yet, recruiting
Jaffna Teaching Hospital
Jaffna, Sri Lanka
Not, yet, recruiting
Kandy National Hospital
Kandy, Sri Lanka
Not, yet, recruiting
Kurunegala Teaching Hospital
Kurunegala, Sri Lanka
Not, yet, recruiting
Kothalawala Defence University Hospital
Werahera, Sri Lanka
Not, yet, recruiting

United Kingdom

Royal Derby Hospital
Derby, United Kingdom
Recruiting
College of Life Sciences, University of Leicester
Leicester, United Kingdom
Recruiting
Barts Health Nhs Trust
London, United Kingdom
Withdrawn
Manchester University Nhs Foundation Trust
Manchester, United Kingdom
Not, yet, recruiting

10 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboWAL0921

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 2 Jul 2024
Primary completion: 31 Mar 2027
Completion: 30 Jun 2027
Last update posted: 3 Aug 2026
Registered enrollment: 96
Registry id: NCT06466135

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.