findmyKOL
Clinical trialNCT06474273RecruitingPhase 3Interventional

TACKLE-IT Trial - Treat Acute T Cell Rejection With Evidence and Confidence in Kidney Transplant Recipients

SponsorUniversity of SydneyEnrollment540Rejection; Transplant, KidneyRejection; Transplant, Pancreas
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

After a kidney or a simultaneous kidney-pancreas transplant, some patients may face problems with their new organs. This happens because the body sometimes makes a mistake and tries to get rid of the organ. This problem is called rejection. One type of rejection is known as Acute T cell mediated rejection (TCMR). This can lead to many problems or even stop the transplant from working. Doctors give strong steroids to treat this problem, but there are no rules for how much steroid to give. Too much steroids can cause problems like heart and bone problems, bad infections, and weight gain. That is why we need to find the right dose of steroids for each person to treat this. TACKLE-IT is a study that will try to find the right steroid dose for treating rejection.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

25 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • John Hunter Hospital

    Lambton, New South Wales, Australia

    Thida Myint, FRACP
    Not, yet, recruiting
  • Prince of Wales Hospital

    Randwick, New South Wales, Australia

    Kenneth Yong, FRACP, PhD
    Not, yet, recruiting
  • the Sydney Children'S Hospital Network

    Westmead, New South Wales, Australia

    Siah Kim, FRACP, PhD
    Not, yet, recruiting
  • Westmead Hospital

    Westmead, New South Wales, Australia

    Germaine Wong, FRACP, Phd
    Recruiting
  • Queensland Children'S Hospital

    South Brisbane, Queensland, Australia

    Anna Francis, PhD, FRACP
    Recruiting
  • Princess Alexandra Hospital

    Woolloongabba, Queensland, Australia

    Carmel Hawley, FRACP, MMSc
    Not, yet, recruiting
  • Royal Adelaide Hospital

    Adelaide, South Australia, Australia

    Michael Collins, FRACP, PhD
    Not, yet, recruiting
  • Monash Medical Centre

    Clayton, Victoria, Australia

    John Kanellis, FRACP, PhDWilliam Mulley, FRACP, PhD
    Not, yet, recruiting
  • Royal Perth Children'S Hospital

    Nedlands, Western Australia, Australia

    Nick Larkins, FRACP, PhD
    Not, yet, recruiting
  • Sir Charles Gairdner Hospital

    Nedlands, Western Australia, Australia

    Wai Lim, FRACP, PHD
    Not, yet, recruiting
  • Royal Perth Hospital

    Perth, Western Australia, Australia

    Mark Thomas, FRACP
    Not, yet, recruiting
Canada
  • University of Calgary

    Calgary, Alberta, Canada

    Ngan Lam, MD, MSc
    Not, yet, recruiting
  • University of Alberta

    Edmonton, Alberta, Canada

    Not, yet, recruiting
  • Transplant Manitoba, Adult

    Winnipeg, Manitoba, Canada

    Julie Ho, FRCPC
    Not, yet, recruiting
  • Transplant Manitoba, Pediatric

    Winnipeg, Manitoba, Canada

    Aviva Goldberg, MD
    Not, yet, recruiting
  • Dalhousie University

    Halifax, Nova Scotia, Canada

    Amanda Vinson, MD
    Not, yet, recruiting
  • Western University

    London, Ontario, Canada

    Matthew Weir, MD, FRCPC
    Not, yet, recruiting
  • University of Toronto

    Toronto, Ontario, Canada

    Joseph Kim, MD, PhD
    Not, yet, recruiting
  • University of Toronto - Hospital for Sick Kids

    Toronto, Ontario, Canada

    Chia Wei Teoh, MB B.Ch., BAO, LRCSI, MRCPI
    Not, yet, recruiting
  • University of Toronto - St Michael Hospital

    Toronto, Ontario, Canada

    Darren Yuen, MD, PhD
    Not, yet, recruiting
  • Mcgill University

    Montreal, Quebec, Canada

    Shaifali Sandal, MD
    Not, yet, recruiting
  • University of Montreal

    Montreal, Quebec, Canada

    Daniel Fantus, MD, FRCPC
    Not, yet, recruiting
  • University of Laval

    Québec, Quebec, Canada

    Sacha De Serres, MD, FRCPC
    Not, yet, recruiting
  • University of Saskatchewan

    Saskatoon, Saskatchewan, Canada

    Rahul Manira, MD, FRCPC
    Not, yet, recruiting
New Zealand
  • Auckland City Hospital

    Grafton, Auckland, New Zealand

    Helen Pilmore
    Not, yet, recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Methylprednisolone →Prednisone →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
13 Mar 2026
Primary completion
30 Jun 2030
Completion
30 Jun 2030
Last update posted
6 May 2026
Registered enrollment
540
Registry id
NCT06474273
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.