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Clinical trialNCT06480838RecruitingObservational

Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury

SponsorUniversity of Texas Southwestern Medical CenterEnrollment130Brain Injury Traumatic ModerateBrain Injury Traumatic SevereTBITBI (Traumatic Brain Injury)Traumatic Brain Injury With Loss of Consciousness
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\< 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Parkland Health and Hospital System

    Dallas, Texas, United States

    Alex Valadka
    Recruiting
  • Texas Health Presbyterian Hospital

    Dallas, Texas, United States

    Kan Ding, MDPhilip Edmundson, MD
    Recruiting
  • Ut Southwestern Medical Center

    Dallas, Texas, United States

    C M Cullum, PhDDavid Zhu, PhDKan Ding, MDRong Zhang, PhDYulun Liu, PhD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
1 Sept 2023
Primary completion
31 Mar 2028
Completion
31 May 2029
Last update posted
2 Jul 2026
Registered enrollment
130
Registry id
NCT06480838
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.