Clinical trialNCT06495710RecruitingInterventional

Arterial Stiffness and Blood Pressure

SponsorVA Office of Research and DevelopmentEnrollment228AgingHypertensionVascular Stiffness

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and underlying individual genetic information. Older Veterans with hypertension are less likely to be treated to goal blood pressure because there are conflicting recommendations for what constitutes "optimal" in older adults. The investigators have developed a novel way to non-invasively assess the components of blood vessel stiffness that is related to blood pressure (load-dependent stiffness). This project will generate new knowledge about how different blood pressure treatment goals (intensive vs standard) impact different components of arterial stiffness and if these differences can be explained through genetic analysis. Results from this project will offer the VA an updated blueprint for personalizing blood pressure care in older adults, ultimately improving cardiovascular health.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Adam Gepner
William S. Middleton Memorial Veterans Hospital, Madison, WI
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Birmingham Va Medical Center, Birmingham, Al
Birmingham, Alabama, United States
Not, yet, recruiting
Tennessee Valley Healthcare System Nashville Campus, Nashville, Tn
Nashville, Tennessee, United States
Enrolling, by, invitation
William S. Middleton Memorial Veterans Hospital, Madison, Wi
Madison, Wisconsin, United States
Adam Gepner
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 May 2025
Primary completion: 31 Dec 2027
Completion: 31 Dec 2028
Last update posted: 13 Apr 2026
Registered enrollment: 228
Registry id: NCT06495710

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.