Clinical trialNCT06504589RecruitingObservational

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

SponsorNicole HamblettEnrollment400Cystic Fibrosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not take CFTR modulators. This data may be used to inform CF research, help design CF clinical trials and support the development of new treatments for people with CF who do not take CFTR modulators. Another goal of this study is to learn about research involvement for people with CF who do not take CFTR modulators, engage them in research, and give them an opportunity to learn about what is involved in participating in a CF research study.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Deepika Polineni, MD, MPH
Washington University School of Medicine
Principal Investigator
clinicaltrials.gov ↗
Felix Ratjen, MD
University of Toronto
Principal Investigator
clinicaltrials.gov ↗
Nicole Mayer-Hamblett, PhD
Seattle Children's Hospital
Principal Investigator
clinicaltrials.gov ↗
Scott Donaldson, MD
University of North Carolina, Chapel Hill
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

68 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

the Children'S Hospital Alabama, University of Alabama at Birmingham
Birmingham, Alabama, United States
Recruiting
Phoenix Children'S Hospital
Phoenix, Arizona, United States
Recruiting
Tucson Cystic Fibrosis Center
Tucson, Arizona, United States
Recruiting
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Recruiting
University of California San Diego
La Jolla, California, United States
Not, yet, recruiting
Childrens Hospital Los Angeles
Los Angeles, California, United States
Recruiting
Stanford University Medical Center
Palo Alto, California, United States
Recruiting
University of California, San Francisco - Adult Center
San Francisco, California, United States
Recruiting
University of California, San Francisco - Peds Center
San Francisco, California, United States
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Recruiting
National Jewish Health
Denver, Colorado, United States
Recruiting
University of Florida
Gainesville, Florida, United States
Recruiting
University of Miami
Miami, Florida, United States
Recruiting
Central Florida Pulmonary Group
Orlando, Florida, United States
Recruiting
Tampa General Hospital
Tampa, Florida, United States
Recruiting
Children'S Healthcare of Atlanta and Emory University
Atlanta, Georgia, United States
Recruiting
Augusta University
Augusta, Georgia, United States
Recruiting
Saint Luke'S Cystic Fibrosis Center of Idaho
Boise, Idaho, United States
Recruiting
Northwestern University
Chicago, Illinois, United States
Recruiting
Riley Hospital for Children
Indianapolis, Indiana, United States
Recruiting
University of Kansas Medical Center
Kansas City, Kansas, United States
Recruiting
University of Kentucky
Lexington, Kentucky, United States
Recruiting
Tulane University
Metairie, Louisiana, United States
Recruiting
John Hopkins Hospital
Baltimore, Maryland, United States
Not, yet, recruiting
Boston Children'S Hospital
Boston, Massachusetts, United States
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
Recruiting
University of Massachusetts Memorial Health Care
Worcester, Massachusetts, United States
Recruiting
University of Michigan, Michigan Medicine
Ann Arbor, Michigan, United States
Recruiting
Wayne State University Harper University Hospital
Detroit, Michigan, United States
Recruiting
Corewell Health Helen Devos
Grand Rapids, Michigan, United States
Recruiting
the Minnesota Cystic Fibrosis Center
Minneapolis, Minnesota, United States
Recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Recruiting
Billings Clinic
Billings, Montana, United States
Recruiting
University of Nebraska Medical Center
Omaha, Nebraska, United States
Recruiting
Morristown Medical Center
Morristown, New Jersey, United States
Recruiting
the Cystic Fibrosis Center of Western New York
Buffalo, New York, United States
Not, yet, recruiting
Cohen Children'S Medical Center of New York
New Hyde Park, New York, United States
Recruiting
Columbia University Cystic Fibrosis Program
New York, New York, United States
Recruiting
University of Rochester Medical Center Strong Memorial
Rochester, New York, United States
Recruiting
New York Medical College at Westchester Medical Center
Valhalla, New York, United States
Recruiting

28 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 18 Sept 2024
Primary completion: 14 Aug 2029
Completion: 14 Aug 2029
Last update posted: 1 Oct 2025
Registered enrollment: 400
Registry id: NCT06504589

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.