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Clinical trialNCT06507618RecruitingPhase 3Interventional

Pre-Operative Window of ET to Inform RT Decisions (POWER II)

SponsorUniversity of VirginiaEnrollment354Breast Cancer Female
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a Phase III, multisite exploratory study for women ≥ 65 years of age with early stage estrogen receptor positive (ER+) breast cancer. These individuals will be treated randomly assigned to one of two groups: Intervention, treated with 3 months of pre-operative endocrine therapy (pre-ET) OR Control, participants follow standard of care and proceed directly to breast cancer surgery. Both arms will be assessed for tolerance and compliance to the endocrine therapy by patient reported outcome (PRO) measures (patient surveys).
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Yale University

    New Haven, Connecticut, United States

    Recruiting
  • University of Virginia

    Charlottesville, Virginia, United States

    Recruiting
  • University of Virginia Community Health

    Culpeper, Virginia, United States

    Recruiting
  • Inova Schar Cancer

    Fairfax, Virginia, United States

    Recruiting
  • Riverside Health System

    Newport News, Virginia, United States

    Recruiting
  • Virginia Commonwealth University

    Richmond, Virginia, United States

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Tamoxifen →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
19 Jul 2024
Primary completion
30 Jun 2029
Completion
1 Mar 2034
Last update posted
30 Jun 2026
Registered enrollment
354
Registry id
NCT06507618
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.