Clinical trialNCT06541847RecruitingPhase 2Interventional

A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1

SponsorHealx LimitedEnrollment25Neurofibromatosis Type 1

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The trial will be an open label, single arm, phase 2 study to assess the tolerability and efficacy of HLX-1502 in participants with NF1 that are 16 years or older in age with progressive and/or symptomatic PN. This study will also investigate the safety and efficacy of HLX-1502 in a small cohort of 12 to 15 year olds.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Kathryn Nevel
Indiana University
Study Chair
clinicaltrials.gov ↗
Michael Fisher
Children's Hospital of Philadelphia
Study Chair
clinicaltrials.gov ↗
Miriam Bornhorst
Lurie's Children's Hospital
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
Girish DhallLaura Katherine Metrock
Recruiting
Children'S Hospital Los Angeles
Los Angeles, California, United States
Anat Erdreich-EpsteinAshley MargolKaaren WatersKasey RanganKatrina O'HalloranNathan RobisonSara-Jane OneyeamaTena RosserTom DavidsonVless Trinidad
Recruiting
Stanford University
Palo Alto, California, United States
Cynthia CampenKatherine RyanPaul FisherSonia Partap
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Holly LindsayMolly HemenwayNicholas ForemanShelby Winzent-Oonk
Recruiting
Children'S National Hospital
Washington D.C., District of Columbia, United States
AeRang KimAmy HontBenjamin SiegelBrian RoodEugene HwangHolly MeanyLindsay KilburnLiny JohnRoger Packer
Recruiting
Ann & Robert H. Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
Alicia LenzenAngela WaandersAshley PlantMaggie SeblaniMiriam Bornhorst
Recruiting
University of Chicago
Chicago, Illinois, United States
James TonsgardShawn Damodharan
Recruiting
Indiana University
Indianapolis, Indiana, United States
Brian WeissJayne VonbergenKathryn NevelScott CovenSteven Rhodes
Recruiting
Johns Hopkins Hospital
Baltimore, Maryland, United States
Carlos RomoJaishri BlakeleyKelly WypychShannon Langmead
Recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Allison KingAmy ArmstrongAndrea OgleAndrew ClusterAngela HirbeAshley MeyerBrian Van TineBryan SiskCamille SkaerChristina CareyDaniel WillisDavid WilsonFrederick HuangLeslie GloverLinda GoldenbergLoren AbernathyMia WeissMohamed AbdelbakiMolly WarnerNicole BrossierSanita Burgic
Recruiting
New York University Langone Health
New York, New York, United States
Devorah SegalJessica ClymerJordie BlumKaleb Yohay
Recruiting
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Aaron MochizukiBenjamin MizukawaChristine PhillipsEllen ChangErin BreeseJohn PerentesisJonathan BenderJoseph PresseyKaren BurnsLaQuita JonesLauren PommertLynn LeeNatasha Pillay-SmileyPeter De BlankRichard GrahamRobin NorrisThomas GallettaTrent Hummel
Recruiting
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Amish ShahCassie KlineChelsea KotchJane MinturnJean BelascoJessica FosterKristina ColeMichael FisherStephanie Brosius
Recruiting
University of Texas Southwestern Medical Center
Dallas, Texas, United States
Alexis KennedyDaniel BowersDevon KnottsElizabeth MaherEvan NochJonathan WickiserJustin JordanLaura KlesseMichael Youssef
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

HLX-1502

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 10 Feb 2025
Primary completion: 30 Jun 2027
Completion: 31 Jan 2028
Last update posted: 29 Jul 2026
Registered enrollment: 25
Registry id: NCT06541847

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.