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Clinical trialNCT06568484RecruitingPhase 2/PHASE3Interventional

Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TB

SponsorJohns Hopkins UniversityEnrollment2,530Tuberculosis, Latent
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

A seamless, staged Phase II/III, open-label, multicenter, non-inferiority trial, to compare the efficacy and safety of 4 weeks of bedaquiline (BDQ) versus a a standard regimen for preventing regimen for preventing confirmed or probable tuberculosis disease (TBD) during 72 weeks of follow-up among people living with HIV (PLHIV) and high-risk Close Contacts (CC) of adults with Drug Susceptible (DS) or Rifampin Resistant (RR) TB.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Mongolia
  • National Center for Communicable Disease (nccd)

    Ulaanbaatar, Mongolia

    Not, yet, recruiting
Peru
  • Hnseb (hospital Nacional Sergio E. Bernales)

    Lima, Peru

    Not, yet, recruiting
  • Ses Policlinico

    Lima, Peru

    Recruiting
Tanzania
  • Nimr-Mmrc

    Mbeya, Tanzania

    Not, yet, recruiting
  • Kilimanjaro Clinical Research Institute

    Moshi, Tanzania

    Recruiting
Uganda
  • Joint Clinical Research Centre

    Kampala, Uganda

    Recruiting
  • Mu-Jhu Care Ltd.

    Kampala, Uganda

    Recruiting
  • Makerere Lung Institute

    Kampala, Uganda

    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bedaquiline →Levofloxacin →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
8 May 2026
Primary completion
31 Jul 2027
Completion
30 Sept 2027
Last update posted
18 Aug 2026
Registered enrollment
2,530
Registry id
NCT06568484
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.