Clinical trialNCT06592924RecruitingPhase 3Interventional

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

SponsorCanadian Cancer Trials GroupEnrollment830Prostate Cancer (Adenocarcinoma)

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs? This study would like to find out if this approach is better or worse than the usual approach for prostate cancer. The usual approach for patients who are not in a study is hormone treatment with Androgen Deprivation Therapy (ADT) and Androgen-Receptor Pathway Inhibitor (ARPI).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Alexandra Sokolova
Oregon Health and Science University, Portland, OR, USA
Study Chair
clinicaltrials.gov ↗
Michael Ong
Ottawa Hospital Research Institute, Ottawa ON Canada
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

395 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Cross Cancer Institute
Edmonton, Alberta, Canada
Michael P. Kolinsky
Recruiting
Bcca-Vancouver Cancer Centre
Vancouver, British Columbia, Canada
Corinne Maurice Dror
Recruiting
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Hanbo Zhang
Recruiting
Atlantic Health Sciences Corporation-Saint John Regional Hospital
Saint John, New Brunswick, Canada
Samantha L. Gray
Recruiting
Health Sciences North
Greater Sudbury, Ontario, Canada
Eoghan R. Malone
Recruiting
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada
Sebastien J. Hotte
Recruiting
Kingston Health Sciences Centre
Kingston, Ontario, Canada
Martin Smoragiewicz
Recruiting
Waterloo Regional Health Network
Kitchener, Ontario, Canada
Anupam Batra
Recruiting
London Regional Cancer Program
London, Ontario, Canada
Lorin Dodbiba
Recruiting
Trillium Health Partners - Credit Valley Hospital
Mississauga, Ontario, Canada
Daniel Yokom
Recruiting
Ottawa Hospital and Cancer Center-General Campus
Ottawa, Ontario, Canada
Michael Ong
Recruiting
Niagara Health System-Saint Catharines General
Saint Catharines, Ontario, Canada
David W. Wasserman
Recruiting
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Daniel J. Khalaf
Recruiting
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada
Di Maria Jiang
Recruiting
Csss Champlain-Charles Le Moyne
Greenfield Park, Quebec, Canada
Trung N. Nguyen
Recruiting
Ciusssemtl-Hopital Maisonneuve-Rosemont
Montreal, Quebec, Canada
Caroline Letendre
Recruiting
Jewish General Hospital
Montreal, Quebec, Canada
April Rose
Recruiting
Cha Hopital L'Enfant-Jesus
Québec, Quebec, Canada
Eric Levesque
Recruiting
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
Nayyer Iqbal
Recruiting

Mexico

Instituto Nacional de Cancerologia de Mexico
Mexico City, Tlalpan, Mexico
Nora Sobrevilla-Moreno
Recruiting

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Katmai Oncology Group
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Fairbanks Memorial Hospital
Fairbanks, Alaska, United States
John M. Schallenkamp
Recruiting
Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Shahzad Siddique
Recruiting
Kaiser Permanente-Anaheim
Anaheim, California, United States
Helen H. Moon
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Shahzad Siddique
Recruiting
Kaiser Permanente-Baldwin Park
Baldwin Park, California, United States
Helen H. Moon
Recruiting
Kaiser Permanente-Bellflower
Bellflower, California, United States
Helen H. Moon
Recruiting
Tower Cancer Research Foundation
Beverly Hills, California, United States
Edwin M. Posadas
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Charles W. Drescher
Recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Tanya B. Dorff →
Recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
Stanford Cancer Center Emeryville
Emeryville, California, United States
Ali R. Khaki
Recruiting
Kaiser Permanente-Fontana
Fontana, California, United States
Helen H. Moon
Recruiting

355 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

ADTAbiraterone →Apalutamide →Darolutamide →Docetaxel →Enzalutamide →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 May 2025
Primary completion: 14 Mar 2031
Completion: 15 Apr 2031
Last update posted: 14 Jul 2026
Registered enrollment: 830
Registry id: NCT06592924

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.