Clinical trialNCT06614322RecruitingPhase 2Interventional

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

SponsorUniversity of RochesterEnrollment190Chemotherapy Induced Peripheral Neuropathy (CIPN)Diabetic Peripheral Neuropathic Pain (DPN)Idiopathic Peripheral NeuropathyPainful Peripheral Neuropathy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants with painful peripheral neuropathy. The analgesic effect is evaluated by measuring pain intensity and Patient Global Impression of Change (PGIC). This study is a 3-period cross-over trial. This means researchers will compare 3 different drugs (pregabalin, duloxetine, and placebo) over a period of 19 weeks. Participants will: * Undergo a quantitative sensory testing (QST) exam. * Provide a blood sample. * Complete questionnaires on the computer. * Take the study drug as instructed.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Jennifer Gewandter, PhD, MPH
University of Rochester
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Beth Israel Deaconess Medical Center for Autonomic and Peripheral Nerve Disorders
Boston, Massachusetts, United States
Roy Freeman, MD
Recruiting
Ichan School of Medicine at Mount Sinai
New York, New York, United States
Jessica Robinson-Papp, MD
Not, yet, recruiting
University of Rochester
Rochester, New York, United States
Jennifer Gewandter, PhD, MPH
Recruiting
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Ajay Wasan, MD
Not, yet, recruiting
University of Utah
Salt Lake City, Utah, United States
Rob Singleton, MD
Not, yet, recruiting
University of Vermont
Burlington, Vermont, United States
Noah Kolb, MD
Recruiting
Vcu Medical Center
Richmond, Virginia, United States
Gordon Smith, MD
Not, yet, recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Duloxetine →Pregabalin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Jan 2026
Primary completion: 30 Jun 2028
Completion: 30 Jun 2028
Last update posted: 23 Apr 2026
Registered enrollment: 190
Registry id: NCT06614322

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.