Clinical trialNCT06616974Active, not recruitingPhase 2Interventional

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

SponsorTectonic TherapeuticEnrollment191Heart Failure With Preserved Ejection FractionPulmonary Hypertension

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Robert Rogers, MD
Tectonic Therapeutic
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

72 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Armenia

Yerevan
Yerevan, Armenia
Yerevan
Yerevan, Armenia
Yerevan
Yerevan, Armenia

Australia

Camperdown
Camperdown, New South Wales, Australia
Macquarie
Macquarie, New South Wales, Australia
New Lambton
New Lambton, New South Wales, Australia
Sydney
Sydney, New South Wales, Australia
Wollongong
Wollongong, New South Wales, Australia
Chermside
Chermside, Queensland, Australia
Hobart
Hobart, Tasmania, Australia
Malvern
Malvern, Victoria, Australia
Camperdown
Camperdown, Australia
New Lambton
New Lambton, Australia

Austria

Austria
Vienna, Austria

Belgium

Brussel
Brussels, Belgium

Bulgaria

Pleven
Pleven, Bulgaria
Plovdiv
Plovdiv, Bulgaria

Georgia

Tbilisi
Tbilisi, Tb, Georgia
Tbilisi
Tbilisi, Georgia
Tbilisi
Tbilisi, Georgia
Tbilisi
Tbilisi, Georgia

Germany

Mainz
Mainz, Germany

Latvia

Riga
Riga, Latvia

Moldova

Chisinau
Chisinau, Moldova

New Zealand

Christchurch
Christchurch, New Zealand

Poland

Białystok
Bialystok, Poland
Krakow
Krakow, Poland
Łodź
Lodz, Poland
Lublin
Lublin, Poland
Warsaw
Warsaw, Poland
Wrocław
Wroclaw, Poland

Portugal

Almada
Almada, Portugal
Lisboa
Lisbon, Portugal
Porto
Porto, Portugal

Romania

Bucuresti
Bucharest, Romania
Craiova
Craiova, Romania
Targu Mures
Târgu Mureş, Romania

Serbia

Nis, Belgrade
Belgrade, Nis, Serbia
Serbia
Belgrade, Serbia
Sremska Kamenica
Kamenitz, Serbia

32 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 4 Sept 2024
Primary completion: 24 Nov 2026
Completion: 5 Jan 2027
Last update posted: 7 Jul 2026
Registered enrollment: 191
Registry id: NCT06616974

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.