Clinical trialNCT06630104RecruitingInterventional

Understanding the Mechanisms of Clonal and Non-clonal Cytopenia Following CAR-T Therapy for Multiple Myeloma or CD19+ Lymphoproliferative Disorder (LPD)

SponsorMayo ClinicEnrollment82Lymphoproliferative DisorderMultiple Myeloma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This clinical trial evaluates the impact of preexisting and therapy-emergent germline and somatic variants on cytopenia in patients with multiple myeloma or CD19 positive lymphoproliferative disorder (LPD) following chimeric antigen receptor T-cell (CAR-T) therapy. The most common adverse event after CAR-T therapy is lower than normal blood cells (cytopenia) and up to one third of patients experience cytopenia that last longer than 30 days post-infusion. Germline and somatic variants are changes in genes found using cancer genomic tests. Cancer genetic/genomic testing is a series of tests that find specific changes in cancer cells or in blood deoxyribonucleic acid. Identifying gene mutations may help identify the risk of cytopenia in patients with multiple myeloma or CD19 positive LPD following CAR-T therapy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Mithun V. Shah, MD
Mayo Clinic in Rochester
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Cecilia Y. Arana Yi, MD
Recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Talha Badar, MD
Recruiting
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States
Mina S. Hanna, MD
Recruiting
Mayo Clinic Health System-Mankato
Mankato, Minnesota, United States
Amrit B. Singh, MBBS
Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Mithun V. Shah, MD, PhD
Recruiting
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin, United States
Eyad S. Al-Hattab, MD
Recruiting
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, United States
Scott H. Okuno, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Nov 2024
Primary completion: 16 Dec 2027
Completion: 16 Dec 2027
Last update posted: 12 Aug 2026
Registered enrollment: 82
Registry id: NCT06630104

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.