Clinical trialNCT06649812RecruitingPhase 2Interventional

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

SponsorNational Cancer Institute (NCI)Enrollment120High Grade B-Cell Lymphoma With MYC and BCL6 RearrangementsRecurrent Diffuse Large B-Cell LymphomaRecurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell TypeRecurrent Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedRecurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsRecurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements+9 more conditions

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Christopher J Melani
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

85 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Banner University Medical Center - Tucson
Tucson, Arizona, United States
Suspended
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
Suspended
Cedars-Sinai Medical Center
Los Angeles, California, United States
Justin M. Darrah
Recruiting
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, United States
Shalin Kothari
Recruiting
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, United States
Shalin Kothari
Recruiting
Yale University
New Haven, Connecticut, United States
Shalin Kothari
Recruiting
Kootenai Health - Coeur D'Alene
Coeur d'Alene, Idaho, United States
Suspended
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, United States
Suspended
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, United States
Suspended
Northwestern University
Chicago, Illinois, United States
Reem Karmali
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Suspended
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Reem Karmali
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Suspended
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Reem Karmali
Recruiting
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, United States
Reem Karmali
Recruiting
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, United States
Reem Karmali
Recruiting
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States
Reem Karmali
Recruiting
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Suspended
Carle Bromenn Medical Center
Normal, Illinois, United States
Suspended
Carle Cancer Institute Normal
Normal, Illinois, United States
Suspended
Northwestern Medicine Oak Brook
Oak Brook, Illinois, United States
Reem Karmali
Recruiting
Northwestern Medicine Orland Park
Orland Park, Illinois, United States
Reem Karmali
Recruiting
Memorial Hospital East
Shiloh, Illinois, United States
Brad S. Kahl
Recruiting
Carle Cancer Center
Urbana, Illinois, United States
Suspended
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States
Reem Karmali
Recruiting
Mary Greeley Medical Center
Ames, Iowa, United States
Joseph J. Merchant
Recruiting
Mcfarland Clinic - Ames
Ames, Iowa, United States
Joseph J. Merchant
Recruiting
Mcfarland Clinic - Boone
Boone, Iowa, United States
Suspended
Mercy Hospital
Cedar Rapids, Iowa, United States
Deborah W. Wilbur
Recruiting
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, United States
Deborah W. Wilbur
Recruiting
Mcfarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, United States
Joseph J. Merchant
Recruiting
Mcfarland Clinic - Jefferson
Jefferson, Iowa, United States
Suspended
Mcfarland Clinic - Marshalltown
Marshalltown, Iowa, United States
Joseph J. Merchant
Recruiting
Ochsner Medical Center Jefferson
New Orleans, Louisiana, United States
Ashley D. Staton
Recruiting
National Institutes of Health Clinical Center
Bethesda, Maryland, United States
Christopher J. Melani
Recruiting
Essentia Health Saint Joseph'S Medical Center
Brainerd, Minnesota, United States
Bret E. Friday
Recruiting
Essentia Health - Deer River Clinic
Deer River, Minnesota, United States
Bret E. Friday
Recruiting
Essentia Health Cancer Center
Duluth, Minnesota, United States
Bret E. Friday
Recruiting
Essentia Health Hibbing Clinic
Hibbing, Minnesota, United States
Bret E. Friday
Recruiting
Essentia Health Sandstone
Sandstone, Minnesota, United States
Bret E. Friday
Recruiting

45 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 7 Oct 2025
Primary completion: 1 Sept 2027
Completion: 1 Sept 2027
Last update posted: 10 Jul 2026
Registered enrollment: 120
Registry id: NCT06649812

Cross-registrations

Other registry (CTRP (Clinical Trial Reporting ProgramNCI-2024-08642

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.