Clinical trialNCT06671002RecruitingPhase 4Interventional

Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial

SponsorUniversity of MichiganEnrollment900Pain, Post OperativeSurgery

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll. Eligible participants will be randomized to prescription of 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) plus acetaminophen or low dose opioids with the NSAIDs plus acetaminophen. The key question the study seeks to answer is which option will have the best outcomes and with the fewest side effects?

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Mark Bicket, MD, PhD
University of Michigan
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Phoenix Children'S
Phoenix, Arizona, United States
Active, not recruiting
Children'S Hospital Los Angeles (chla)
Los Angeles, California, United States
Lorraine Kelley-Quon, MD
Recruiting
Lucile Packard Children'S Hospital Stanford
Palo Alto, California, United States
Jennifer Rabbitts, MD
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Active, not recruiting
Kapi'Olani Medical Center for Women & Children
Honolulu, Hawaii, United States
Active, not recruiting
University of Michigan
Ann Arbor, Michigan, United States
Mark Bicket, MD, PhD
Recruiting
Cincinnati Children'S
Cincinnati, Ohio, United States
Justin Lee, MD
Not, yet, recruiting
Nationwide Children'S (nch)
Columbus, Ohio, United States
Sara Mansfield, MD
Recruiting
Children'S Wisconsin
Milwaukee, Wisconsin, United States
Active, not recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Acetaminophen →Ibuprofen →NSAIDOpioid

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 10 Jan 2025
Primary completion: 16 Oct 2026
Completion: 31 Oct 2027
Last update posted: 20 Oct 2026
Registered enrollment: 900
Registry id: NCT06671002

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.