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Clinical trialNCT06687941RecruitingPhase 1Interventional

A Study to Evaluate the Tolerability, Safety, and PK of AST-201 in Patients With GPC3-positive Advanced Solid Tumors

SponsorAptamer Sciences, Inc.Enrollment70Carcinoma, HepatocellularCarcinoma, Non-Small-Cell LungLiver NeoplasmsNeoplasms
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is the first in human trial clinical study of AST-201 in patients with GPC3-positive advanced solid tumors. This study aims to evaluate the safety, tolerability, pharmacokinetic properties, and preliminary efficacy of AST-201 across various tumor types.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

South Korea
  • National Cancer Center, Korea

    Goyang-si, Gyeonggi-do, South Korea

    Bo Hyun Kim, MD, PhDSang Myung Woo, MD, PhD
    Recruiting
  • Cha Bundang Medical Center

    Seongnam, South Korea

    Hong Jae Chon, MD, PhD
    Recruiting
  • Samsung Medical Center

    Seoul, South Korea

    Jung Yong Hong, MD, PhD
    Recruiting
  • Severance Hospital

    Seoul, South Korea

    Hye Ryun Kim, MD, PhD.
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AST-201
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
11 Mar 2025
Primary completion
31 Dec 2027
Completion
31 May 2028
Last update posted
27 Mar 2026
Registered enrollment
70
Registry id
NCT06687941
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.