Clinical trialNCT06730945WithdrawnPhase 4Interventional

Effect of Oral Isosorbide Mononitrate Plus Amlodipine Antispasm Therapy on Outcomes of Radial Artery Grafts After CABG

SponsorRuijin HospitalEnrollment0Coronary Artery Bypass Graft Surgery (CABG)Graft FailureRadial Artery Grafts

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this clinical trial is to to evaluate the effect of oral isosorbide mononitrate plus amlodipine antispasm therapy on outcomes of radial artery grafts in patients underwent primary isolated CABG. The main question it aims to answer is: Whether the oral isosorbide mononitrate plus amlodipine antispasm therapy could reduce the failure outcome of radial artery grafts after CABG . Researchers will compare isosorbide mononitrate plus amlodipine to none to see if isosorbide mononitrate plus amlodipine works. Participants will 1. Take oral isosorbide mononitrate (20-40mg daily) plus amlodipine (2.5-5mg daily) therapy for 24 weeks after CABG. 2. Clinical follow-up at Week 1, 4, 12, and 24 after CABG. 3. Protocol-driven CCTA at Week 24 after CABG.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Mario FL Gaudino, MD
Weill Cornell Medicine NewYork Presbyterian Hospital, NY, US
Principal Investigator
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Qiang Zhao, MD
Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Principal Investigator
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Yunpeng Zhu, MD
Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
Study Director
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

China

Ruijin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, China

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Oral isosorbide mononitrate 4+ amlodipine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 2025
Primary completion: 31 Dec 2028
Completion: 31 Dec 2030
Last update posted: 17 Sept 2025
Registered enrollment: 0
Registry id: NCT06730945

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.