Clinical trialNCT06743113Not, yet, recruitingInterventional

Hypoxic Red Blood Cells in Sickle Cell Anemia

SponsorHemanextEnrollment48Sickle Cell AnaemiaSickle Cell Anemia (HbSS, or HbSβ-thalassemia0)Sickle Cell Anemia CrisisSickle Cell Anemia in Children

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The overall objective of this study is to evaluate the effectiveness and safety of transfusing hypoxic red blood cells manufactured with the Hemanext ONE system in patients with sickle cell anemia. The Hemanext ONE device was cleared through the De Novo process in September 2023.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Biree Andemariam, MD
New England Sickle Cell Institute, University of Connecticut
Principal Investigator
clinicaltrials.gov ↗
Laurel Omert, MD, FACS
Hemanext Inc.
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

New England Sickle Cell Institute, University of Connecticut
Farmington, Connecticut, United States
Biree Andemariam, MD
Emory University School of Medicine
Atlanta, Georgia, United States
Ross Fasano, MD
University of Illinois at Chicago
Chicago, Illinois, United States
John Hopkins University School of Medicine
Baltimore, Maryland, United States
Elizabeth Crowe, MD, PhD
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
Olubusola B Oluwole, MD

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Sept 2026
Primary completion: 1 Apr 2029
Completion: 1 Oct 2029
Last update posted: 17 Aug 2026
Registered enrollment: 48
Registry id: NCT06743113

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.