Clinical trialNCT06748040CompletedInterventional

Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy

SponsorDuke UniversityEnrollment1,874Chronic Kidney DiseaseHypertension

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a substudy of GUARDD-US (Genetic testing to Understand and Address Renal Disease Disparities across the United States, NCT04191824). Its primary purpose is to determine the effect of knowledge of genetic test results that predict efficacy of various antihypertensive medications on change in SBP (systolic blood pressure) from baseline to 3 months in APOL1 (apolipoprotein L1) negative individuals at participating sites.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Carol Horowitz, MD
Icahn School of Medicine at Mount Sinai
Principal Investigator
clinicaltrials.gov ↗
Hrishikesh Chakraborty, DrPH
Duke University
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Florida - Gainesville
Gainesville, Florida, United States
University of Florida - Jacksonville
Jacksonville, Florida, United States
Eskenazi Health
Indianapolis, Indiana, United States
Indiana University
Indianapolis, Indiana, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
the Institute for Family Health
New York, New York, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 10 Jul 2020
Primary completion: 9 Apr 2024
Completion: 17 May 2024
Last update posted: 17 Jun 2025
Registered enrollment: 1,874
Registry id: NCT06748040

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.