Clinical trialNCT06809868RecruitingObservational

Role of Transposable Elements in Septic Immune Aging

SponsorUniversity of California, San FranciscoEnrollment116SepsisSepsis With Acute Organ DysfunctionSepsis With Multiple Organ Dysfunction (MOD)Sepsis and Septic ShockSepsis at Intensive Care UnitSepsis, Septic Shock+2 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Alexendar R Perez, M.D., Ph.D
University of California, San Francisco
Principal Investigator
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Judith Hellman, M.D.
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗
Matthieu Legrand, M.D., Ph.D
University of California, San Francisco
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, San Francisco
San Francisco, California, United States
Alexendar R Perez, M.D., Ph.DElizabeth Whitlock, M.D.Joana Vidigal, Ph.DJudith Hellman, M.D.Matthieu Legrand, M.D., Ph.DOrestes Mavrothalassitis, M.D.
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Feb 2025
Primary completion: 14 Feb 2028
Completion: 14 Aug 2028
Last update posted: 30 Jan 2026
Registered enrollment: 116
Registry id: NCT06809868

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.