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Clinical trialNCT06832722RecruitingPhase 1/PHASE2Interventional

Invobenitug Also Known as Procizumab (PCZ; AK1967) in Critical Cardiovascular Care

Sponsor4TEEN4 Pharmaceuticals GmbHEnrollment90Shock, Cardiogenic
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objective of this Phase 1b/2a trial is to evaluate the safety, tolerability, and exploratory efficacy of invobenitug (also known as procizumab), a monoclonal antibody under development for the treatment of cardiogenic shock (CS). CS is a life-threatening hypoperfusion of vital organs that frequently results in death. In addition to safety and tolerability, pharmacokinetics and pharmacodynamics of invobenitug are evaluated to define the optimum phase 2 dose (P2D) of invobenitug.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

25 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Armenia
  • Erebouni Mwdical Center

    Yerevan, Armenia

    Not, yet, recruiting
  • Yerevan Medical Scientific Center

    Yerevan, Armenia

    Not, yet, recruiting
Belgium
  • Heart Center Aalst, Azorg

    Aalst, Belgium

    Recruiting
  • University Hospital Saint Pierre

    Brussels, Belgium

    Recruiting
  • Ghent University Hospital

    Ghent, Belgium

    Not, yet, recruiting
Czechia
  • University Hospital and Medical Faculty of Pilsen

    Pilsen, Czechia

    Recruiting
  • Charles University Motol University Hospital

    Prague, Czechia

    Recruiting
  • General University Hospital in Prague - Fvn

    Prague, Czechia

    Recruiting
  • Institute of Clinical and Experimental Medicine - Ikem

    Prague, Czechia

    Recruiting
France
  • University Hospital Avicenne Ap-Hp

    Bobigny, France

    Recruiting
  • Département D'Anesthésie-Réanimation

    Dijon, France

    Not, yet, recruiting
  • University Hospital Lille - Institut Cœur Poumon

    Lille, France

    Recruiting
  • University Hospital - Dupuytren Limoges

    Limoges, France

    Recruiting
  • Regional University Hospital Nancy - Hopitaux de Brabois

    Nancy, France

    Recruiting
  • Hôpital Pitié Salpêtrière

    Paris, France

    Not, yet, recruiting
  • Lariboisière Hospital Ap-Hp

    Paris, France

    Recruiting
Netherlands
  • Radboud University Medical Center

    Nijmegen, Netherlands

    Recruiting
Poland
  • Uniersytecki Szpital Kliniczny W Białystoku

    Bialystok, Poland

    Recruiting
  • Uniwersytecki Szpital Kliniczny W Białymstoku

    Bialystok, Poland

    Not, yet, recruiting
  • Górnośląskie Centrum Medyczne W Katowicach / Śląski Uniwersytet Medyczny W Katowicach

    Katowice, Poland

    Recruiting
  • Clinical University Hospital Poznań

    Poznan, Poland

    Recruiting
  • J. Mikulicz Radecki Clinical University Hospital Wrocław

    Wroclaw, Poland

    Recruiting
Serbia
  • Clinical Hospital Center Bezanijska Kosa

    Belgrade, Serbia

    Not, yet, recruiting
  • Institute for Cardiovascular Diseases of Vojvodina

    Kamenitz, Serbia

    Not, yet, recruiting
  • Clinical Center Niš

    Niš, Serbia

    Not, yet, recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AK1967Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
13 Jul 2025
Primary completion
30 Dec 2026
Completion
31 Dec 2026
Last update posted
9 Jul 2026
Registered enrollment
90
Registry id
NCT06832722

Cross-registrations

EU-CTR / CTIS (EudraCT)2024-518450-16-00

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.