Clinical trialNCT06835504RecruitingPhase 3Interventional

Morphine or Ketamine for Analgesia

SponsorColumbia UniversityEnrollment1,010Abdominal PainIsolated Extremity FracturePainPediatrics

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences. Morphine is the standard treatment for children with moderate to severe acute pain, but its use is associated with serious side effects and caregiver and clinician concerns related to opioid administration. The investigators aim to determine if sub-dissociative ketamine is non-inferior to morphine for treating acute pain and a preferable alternative for treating acute pain in children because of its more favorable side effect profile and potential long-term benefits related to pain-related function, analgesic use/misuse, and mental and behavioral health outcomes.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Amy L Drendel, DO, MS
Medical College of Wisconsin
Principal Investigator
clinicaltrials.gov ↗
Daniel S Tsze, MD, MPH
Columbia University
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Children'S Hospital Los Angeles
Los Angeles, California, United States
Not, yet, recruiting
Uc Davis Children'S Hospital
Sacramento, California, United States
Recruiting
Nemours Children'S Hospital
Wilmington, Delaware, United States
Recruiting
Arthur M. Blank Hospital
Atlanta, Georgia, United States
Not, yet, recruiting
Newyork Presbyterian Morgan Stanley Children'S Hospital
New York, New York, United States
Not, yet, recruiting
Upmc Children'S Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States
Not, yet, recruiting
Seattle Children'S Hospital
Seattle, Washington, United States
Recruiting
Children'S Wisconsin
Milwaukee, Wisconsin, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

KetamineMorphine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 17 Oct 2026
Primary completion: 23 Apr 2030
Completion: 23 Apr 2030
Last update posted: 20 Oct 2026
Registered enrollment: 1,010
Registry id: NCT06835504

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.