Clinical trialNCT06855329RecruitingObservational

PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis

SponsorUniversity of Massachusetts, WorcesterEnrollment500Interstitial Lung DiseaseProgressive Pulmonary Fibrosis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a prospective, observational cohort study. Participants with non-idiopatic pulmonary fibrosis, interstitial lung disease (ILD) will be followed for 24 months to systematically collect clinical, imaging, and biospecimen data. The primary objective is to optimize progressive pulmonary fibrosis (PPF) classification and establish PPF incidence for key ILD subtypes. Additional exploratory objectives are to 1) Prospectively validate a novel PPF classifier and assess performance durability over time, and 2) Determine whether multi-dimensional PPF prediction outperforms component approaches.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Cathie Spino, DSc
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
Dinesh Khanna, MD, MS
University of Michigan
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Fernando J Martinez, MD, MS
University of Massachusetts, Worcester
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Imre Noth, MD, MS
University of Virginia
Principal Investigator
clinicaltrials.gov ↗
Justin Oldham, MD, MS
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
Luca Richeldi, MD, PhD
Policlinico Gemelli
Principal Investigator
clinicaltrials.gov ↗
Michael Kreuter, MD
Johannes Gutenberg University Mainz
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

24 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia
Not, yet, recruiting
Prince Charles Hospital
Brisbane, Queensland, Australia
Not, yet, recruiting
Austin Health
Melbourne, Victoria, Australia
Not, yet, recruiting

Austria

Medical University of Graz
Graz, Austria
Not, yet, recruiting

Canada

University of British Columbia
Vancouver, British Columbia, Canada
Recruiting

Czechia

Charles University and Faculty Thomayer Hospital
Prague, Czechia
Not, yet, recruiting

Denmark

Aarhus University Hospital
Aarhus, Denmark
Not, yet, recruiting

France

Bichat, Aphp
Paris, France
Not, yet, recruiting
Chu Pontchaillou
Rennes, France
Not, yet, recruiting

Germany

Prüfzentrum Der Gwt Am Lungenzentrum Coswig
Coswig, Saxony, Germany
Not, yet, recruiting
University Medical Center Mainz
Mainz, Germany
Recruiting
Lmu Munich
Munich, Germany
Not, yet, recruiting

Hungary

Semmelweis University
Budapest, Hungary
Not, yet, recruiting

Ireland

University College Dublin
Dublin, Ireland, Ireland
Recruiting

Italy

Rimini and Riccione Hospitals, Ausl Romagna
Rimini, Italy
Not, yet, recruiting

Netherlands

Erasmus Mc
Rotterdam, South Holland, Netherlands
Recruiting

Spain

Hospital Universitario de la Princesa
Madrid, Spain
Not, yet, recruiting

United States

University of Colorado | Anschutz Medical Campus
Aurora, Colorado, United States
Not, yet, recruiting
University of Massachusetts Chan Medical School
Worcester, Massachusetts, United States
Recruiting
University of Michigan
Ann Arbor, Michigan, United States
Recruiting
Weill Cornell Medicine
New York, New York, United States
Not, yet, recruiting
University of Texas Southwestern
Dallas, Texas, United States
Recruiting
University of Virginia
Charlottesville, Virginia, United States
Recruiting
University of Washington
Seattle, Washington, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 May 2025
Primary completion: 31 Dec 2029
Completion: 31 Dec 2029
Last update posted: 18 Aug 2026
Registered enrollment: 500
Registry id: NCT06855329

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.