Clinical trialNCT06857942RecruitingPhase 4Interventional

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

SponsorEli Lilly and CompanyEnrollment200Overweight or ObesityPsoriasis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe plaque PsO and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

40 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Medical Dermatology Specialists
Phoenix, Arizona, United States
Lindsay Ackerman
Recruiting
First Oc Dermatology Research Inc
Fountain Valley, California, United States
Vivian Laquer
Recruiting
Center for Dermatology Clinical Research, Inc.
Fremont, California, United States
Sunil Dhawan
Recruiting
Metropolis Dermatology
Los Angeles, California, United States
Yen (James) Wang
Recruiting
Northridge Clinical Trials
Northridge, California, United States
Navid Ezra
Recruiting
Neoclinical Research
Hialeah, Florida, United States
Martin Zaiac, MD
Recruiting
Encore Medical Research
Hollywood, Florida, United States
Jerome Obed
Recruiting
Skin Care Research
Hollywood, Florida, United States
Eduardo Weiss
Recruiting
Moore Clinical Research, Inc. D/b/a Trueblue Clinical Research
Tampa, Florida, United States
Stephen Lockwood
Recruiting
Truderm & Truspa
Wellington, Florida, United States
Andleeb Usmani
Recruiting
Southeast Research Specialists
Douglasville, Georgia, United States
Firas George Hougeir
Recruiting
Dawes Fretzin Clinical Research Group, Llc
Indianapolis, Indiana, United States
Scott Fretzin
Recruiting
the Indiana Clinical Trials Center, Pc
Plainfield, Indiana, United States
Scott Guenthner
Recruiting
Equity Medical - Bowling Green
Bowling Green, Kentucky, United States
James Allred
Recruiting
Dermatology and Skin Cancer Specialists, Llc
Rockville, Maryland, United States
Benjamin Lockshin
Recruiting
Metro Boston Clinical Partners
Brighton, Massachusetts, United States
Mark Amster
Recruiting
David Fivenson, Md, Plc
Ann Arbor, Michigan, United States
David Fivenson
Recruiting
Great Lakes Research Group, Inc.
Bay City, Michigan, United States
Brent Boyce
Recruiting
the Derm Institute of West Michigan
Caledonia, Michigan, United States
Kristi Hawley
Recruiting
Skin Cancer and Dermatology Institute - Reno
Reno, Nevada, United States
Michael Heaphy
Recruiting
Stracskin
Portsmouth, New Hampshire, United States
Abel Jarell
Recruiting
Psoriasis Treatment Center of Central New Jersey
East Windsor, New Jersey, United States
Alexa Hetzel
Recruiting
Care Access - Hoboken
Hoboken, New Jersey, United States
Adolfo Fernandez- Obregon
Recruiting
Equity Medical
New York, New York, United States
Michael Cameron
Recruiting
Revival Research Institute, Llc
Cary, North Carolina, United States
Zain Husain
Recruiting
Onsite Clinical Solutions - Huntersville
Huntersville, North Carolina, United States
Nicole Seminara-Zambrzycka
Recruiting
Optima Research - Boardman
Boardman, Ohio, United States
Patrick Shannon
Recruiting
Oregon Dermatology and Research Center
Portland, Oregon, United States
Phoebe Rich, MD
Recruiting
Dermatology Associates of Plymouth Meeting
Plymouth Meeting, Pennsylvania, United States
Jonathan Wolfe
Recruiting
Columbia Dermatology & Aesthetics
Columbia, South Carolina, United States
Jessica Burgy
Recruiting
Delricht Research - Thompson'S Station
Smyrna, Tennessee, United States
Pezhman Shoureshi
Recruiting
Bellaire Dermatology Associates
Bellaire, Texas, United States
Craig Teller
Recruiting
Modern Research Associates, Pllc
Dallas, Texas, United States
Jennifer Cather
Recruiting
Center for Clinical Studies
Houston, Texas, United States
Stephen Tyring
Recruiting
Austin Institute for Clinical Research
Pflugerville, Texas, United States
Edward Lain →
Recruiting
Texas Dermatology and Laser Specialists
San Antonio, Texas, United States
John Browning
Recruiting
Center for Clinical Studies
Webster, Texas, United States
PATRICIA LEE
Recruiting
Tanner Clinic
Layton, Utah, United States
Scott Checketts
Recruiting
Bellevue Dermatology Clinic
Bellevue, Washington, United States
Clive Liu
Recruiting
Dermatology of Seattle
Burien, Washington, United States
Elie Levy
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Tirzepatide →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 19 Mar 2025
Primary completion: 31 May 2028
Completion: 31 May 2028
Last update posted: 3 Jun 2026
Registered enrollment: 200
Registry id: NCT06857942

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.