Clinical trialNCT06909565RecruitingPhase 4Interventional

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

SponsorDuke UniversityEnrollment6,000Percutaneous Coronary InterventionPeripheral Endovascular Intervention

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

V-INTERVENTION will evaluate the effectiveness of inclisiran in preventing major cardiovascular and limb events in patients receiving percutaneous coronary or peripheral arterial revascularization. Inclisiran is a subcutaneous, twice-yearly injection that is FDA-approved as an adjunct with statin therapy and on the market to lower LDL-C in high-risk populations.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Manesh Patel, MD
Duke University
Study Chair
clinicaltrials.gov ↗
Marc Bonaca, MD
Colorado Prevention Center
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Roxana Mehran, MD
Mt Sinai
Study ChairKOL profile →
clinicaltrials.gov ↗
Schuyler Jones, MD
Duke Clinical Research Institute
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

133 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Advanced Cardiovascular Llc
Alexander City, Alabama, United States
Brian Foley, MD
Recruiting
Cardiology, Pc
Birmingham, Alabama, United States
Hutton Brantley, MD
Recruiting
Heart Center Research, Llc
Huntsville, Alabama, United States
Henry Chen, MD
Recruiting
Ims Cardiology
Avondale, Arizona, United States
Riyaz Sumar, MD
Recruiting
Cardiology Associates Research Group
Jonesboro, Arkansas, United States
Ahmed Ahmed, MD
Recruiting
Arkansas Cardiology
Little Rock, Arkansas, United States
David Jones, MD
Recruiting
Pacific Oaks Medical Group
Beverly Hills, California, United States
Ramprasad Dandillaya, MD
Recruiting
Cardiovascular Institute of San Diego
Chula Vista, California, United States
Milind Parikh, MD
Recruiting
John Muir Medical Center - Concord Campus
Concord, California, United States
Jason Liu, MD
Recruiting
Valley Clinical Trials
Covina, California, United States
Withdrawn
Thrive Clinical Research Group
Glendora, California, United States
Fahed Bitar, MD
Recruiting
Radin Cardiovascular Medical Group, Inc
Newport Beach, California, United States
Michael Radin, MD
Recruiting
Valley Clinical Trials, Llc - Flourish Research
Northridge, California, United States
Mehrdad Ariani, MD
Recruiting
Riverside Community Hospital
Riverside, California, United States
Patrick Hu, MD
Recruiting
Kaiser Permanente - San Diego
San Diego, California, United States
Bahram Khadivi, MD
Recruiting
San Diego Cardiac Center
San Diego, California, United States
Jiken Bhatt, MD
Recruiting
Lundquist Institute for Biomedical Innovation at Harbor-Ucla Medical Center
Torrance, California, United States
Quang Bui, MD
Recruiting
the Heart Medical Group
Van Nuys, California, United States
Munaf Shamji, MD
Recruiting
Fomat - West Coast Research Center
Ventura, California, United States
David Blitzer, MD
Recruiting
Interventional Cardiology Medical Group
West Hills, California, United States
Farhad Rafii, MD
Recruiting
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Connie Hess, MD
Recruiting
Clinre 001-001
Thornton, Colorado, United States
Rajesh Sharma, MD
Recruiting
Bridgeport Hospital
Bridgeport, Connecticut, United States
Edward Tuohy, MD
Recruiting
Nuvance Health- Danbury Hospital
Danbury, Connecticut, United States
Hal Wasserman, MD
Recruiting
Cardiology Associates of Fairfield County
Stamford, Connecticut, United States
Edward Portnay, MD
Recruiting
Baycare Medical Group
Clearwater, Florida, United States
Rakesh Sharma, MD
Recruiting
Clearwater Cardiovascular Consultants
Clearwater, Florida, United States
Masood Gilani, MD
Recruiting
Pioneer Clinical Studies
Coral Gables, Florida, United States
Vinod Chainani, MD
Recruiting
Arrow Clinical Trails
Daytona Beach, Florida, United States
Charles Ross, MD
Recruiting
First Coast Cardiovascular Institute, Pa
Jacksonville, Florida, United States
Yazan Khatib, MD
Recruiting
Uf Health Jacksonville
Jacksonville, Florida, United States
Francesco Franchi, MD
Recruiting
Clearwater Cardiovascular and Interventional Consultants- Bardmoor
Largo, Florida, United States
Alexander Heckman, MD
Recruiting
Inpatient Research Clinic, Llc
Miami Lakes, Florida, United States
Francisco Dieguez Jr, MD
Recruiting
Cardiovascular Institute of Northwest Florida
Panama City, Florida, United States
Amir Haghighat, MD
Recruiting
Gulf Coast Heart and Vascular
Panama City, Florida, United States
Ajay Labroo, MD
Recruiting
Charlotte Heart & Vascular Center, Pa
Port Charlotte, Florida, United States
Mario Lopez, MD
Recruiting
Clearwater Cardiovascular Consultants
Safety Harbor, Florida, United States
Active, not recruiting
Tampa Cardiovascular Interventions and Research
Tampa, Florida, United States
Saihari Sadanandan, MD
Recruiting
Northeast Georgia Heart Center, Pc
Gainesville, Georgia, United States
Nima Ghasemzadeh, MD
Recruiting
Javara, Inc.
Peachtree City, Georgia, United States
Withdrawn

93 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Inclisiran →Normal Saline

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 23 Jul 2025
Primary completion: 31 Oct 2029
Completion: 31 Dec 2029
Last update posted: 18 Aug 2026
Registered enrollment: 6,000
Registry id: NCT06909565

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.