Clinical trialNCT06958328RecruitingPhase 3Interventional

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

SponsorNRG OncologyEnrollment356Locally Advanced Unresectable Pancreatic Ductal AdenocarcinomaStage II Pancreatic Cancer AJCC v8Stage III Pancreatic Cancer AJCC v8Stage IV Pancreatic Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of dose-escalated radiation therapy to usual care in patients with locally advanced unresectable pancreatic ductal adenocarcinoma who have received an initial 4-6 months of chemotherapy. Usual care options include additional chemotherapy, observation, or standard lower-dose radiation therapy. These treatments may delay tumor growth but have not been shown to improve survival. Radiation therapy uses high energy X-rays to kill cancer cells and shrink tumors. Dose-escalated radiation therapy involves the precise delivery of higher doses to the tumor, often over a shorter period of time. This trial assesses whether using dose-escalated radiation therapy can prolong survival.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Nina N Sanford
NRG Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

322 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Cross Cancer Institute
Edmonton, Alberta, Canada
Kurian Joseph
Recruiting

United States

Arizona Center for Cancer Care - Gilbert
Gilbert, Arizona, United States
Steven E. Sckolnik
Recruiting
Banner Md Anderson Cancer Center
Gilbert, Arizona, United States
Gary V. Walker
Recruiting
Arizona Center for Cancer Care-Peoria
Peoria, Arizona, United States
Steven E. Sckolnik
Recruiting
Arizona Center for Cancer Care - Phoenix
Phoenix, Arizona, United States
Steven E. Sckolnik
Recruiting
Arizona Center for Cancer Care - Scottsdale
Scottsdale, Arizona, United States
Steven E. Sckolnik
Recruiting
Arizona Center for Cancer Care-Surprise
Surprise, Arizona, United States
Steven E. Sckolnik
Recruiting
Arizona Center for Cancer Care
Tempe, Arizona, United States
Steven E. Sckolnik
Recruiting
Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Shelby Lane
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Shahzad Siddique
Recruiting
Ais Cancer Center at San Joaquin Community Hospital
Bakersfield, California, United States
Luis Mariscal
Recruiting
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Christopher U. Jones
Recruiting
Mills-Peninsula Medical Center
Burlingame, California, United States
Christopher U. Jones
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, United States
Christopher U. Jones
Recruiting
Palo Alto Medical Foundation-Fremont
Fremont, California, United States
Christopher U. Jones
Recruiting
Uci Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
David S. Hong
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Michael V. Sherer
Recruiting
Memorial Medical Center
Modesto, California, United States
Christopher U. Jones
Recruiting
Palo Alto Medical Foundation-Camino Division
Mountain View, California, United States
Christopher U. Jones
Recruiting
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
David S. Hong
Recruiting
Palo Alto Medical Foundation Health Care
Palo Alto, California, United States
Christopher U. Jones
Recruiting
Stanford Cancer Institute Palo Alto
Palo Alto, California, United States
Erqi Pollom
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, United States
Christopher U. Jones
Recruiting
Sutter Roseville Medical Center
Roseville, California, United States
Christopher U. Jones
Recruiting
Sutter Medical Center Sacramento
Sacramento, California, United States
Christopher U. Jones
Recruiting
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States
Christopher U. Jones
Recruiting
Mills Health Center
San Mateo, California, United States
Christopher U. Jones
Recruiting
Ridley-Tree Cancer Center
Santa Barbara, California, United States
Christopher U. Jones
Recruiting
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, United States
Shahzad Siddique
Recruiting
Sutter Pacific Medical Foundation
Santa Rosa, California, United States
Christopher U. Jones
Recruiting
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, United States
Christopher U. Jones
Recruiting
Sutter Solano Medical Center/cancer Center
Vallejo, California, United States
Christopher U. Jones
Recruiting
Bass Medical Group - Lennon
Walnut Creek, California, United States
Active, not recruiting
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, United States
Active, not recruiting
Memorial Hospital North
Colorado Springs, Colorado, United States
Jeffrey R. Olsen
Recruiting
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, United States
Shahzad Siddique
Recruiting
Uchealth Memorial Hospital Central
Colorado Springs, Colorado, United States
Jeffrey R. Olsen
Recruiting
Adventhealth Porter
Denver, Colorado, United States
Matthew B. Spraker
Recruiting
Adventhealth Littleton
Littleton, Colorado, United States
Matthew B. Spraker
Recruiting
Adventhealth Parker
Parker, Colorado, United States
Matthew B. Spraker
Recruiting

282 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Capecitabine →Fluorouracil →Gemcitabine →Irinotecan →Irinotecan SucrosofateLeucovorin →Paclitaxel →Oxaliplatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 21 Aug 2025
Primary completion: 21 Oct 2030
Completion: 21 Oct 2035
Last update posted: 17 Aug 2026
Registered enrollment: 356
Registry id: NCT06958328

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.