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Clinical trialNCT06966479Active, not recruitingPhase 2Interventional

A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)

SponsorUpstream Bio Inc.Enrollment396Severe Asthma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The primary purpose of this study is to evaluate the long-term safety and efficacy of verekitug (UPB-101) in participants who complete the VALIANT study (NCT06196879).

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

102 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina
  • Fundacion Cidea

    CABA, Argentina, Argentina

  • Instituto de Medicina Respiratoria, Imer/ Instituto Médico Damic

    Córdoba, Córdoba Province, Argentina

  • Centro de Medicina Respiratoria

    Concepción del Uruguay, Entre Ríos Province, Argentina

  • Fundacion Scherbovsky

    Mendoza, Mendoza Province, Argentina

  • Investigaciones En Patologias Respiratorias

    San Miguel de Tucumán, Tucumán Province, Argentina

  • Care: Centro de Alergia Y Enfermedades Respiratorias

    Buenos Aires, Argentina

  • Investigaciones En Alergias Y Enfermedades Respiratorias-Inaer

    Buenos Aires, Argentina

  • Centro Medico Dharma

    Mendoza, Argentina

  • Insares

    Mendoza, Argentina

  • Office of Hector H. Altieri Md

    San Miguel de Tucumán, Argentina

  • Instituto Especialidades de la Salud Rosario

    Santa Fe, Argentina

Bulgaria
  • Mhat "rahila Angelova" Pernik

    Pernik, Pernik, Bulgaria

  • Ambulatory for Specialized Outpatient Medical Care - Individual Practice - Dr. Nikolay Evgeniev Ruse Ltd

    Rousse, Ruse, Bulgaria

  • Mc Convex/dcc Convex

    Sofia, Sofia, Bulgaria

  • Medical Center Excelsior (todor Popov)

    Sofia, Sofia, Bulgaria

  • Medical Center New Rehabilitation Center Eood

    Stara Zagora, Stara Zagora, Bulgaria

  • Mc Zdrave 1

    Kozloduy, Vratsa, Bulgaria

  • Medical Center Hera Eood

    Sofia, Bulgaria

  • Medical Center Pulmovizhyn

    Sofia, Bulgaria

Canada
  • Dynamic Drug Advancement

    Ajax, Ontario, Canada

Chile
  • Fundacion Medica San Cristobal

    Santiago, Santiago Metropolitan, Chile

  • Cimer

    Ñuñoa, Santiago Metropolitan, Chile

  • Sociedad Medica Sy G Limitada

    Providencia, Santiago Metropolitana, Chile

  • Estudios Clínicos de Enfermedades Respiratorias E Inmunológicas (cieri)

    Valparaíso, Valparaiso, Chile

Czechia
  • Plicni Stredisko Teplice S.R.O

    Teplice, Czechia

Germany
  • Me Clinical Respiratory Research Hamburg Gmbh

    Hamburg, Free and Hanseatic City of Hamburg, Germany

  • Rcms/lungenpraxis Hohenzollerndamm

    Berlin, Germany, Germany

  • Ikf Pneumologie Frankfurt, Clinical Research Center Respiratory Diseases

    Hessen, Germany, Germany

  • Pois Sachsen Gmbh

    Leipzig, Germany, Germany

  • Kppk Studienzentrum

    Bendorf, Germany

  • Ikf Pneumologie Gmbh & Co. Kg

    Mainz, Germany

Italy
  • Uoc Pneumologia Aou Renato Dulbecco

    Catanzaro, Catanzaro, Italy

Japan
  • Tokyo-Eki Center-Building Clinic

    Tokyo, Chuo-ku, Japan

  • Oji General Hospital

    Hokkaido, Hokkaido, Japan

  • Kishiwada City Hospital

    Osaka, Japan, Japan

  • Osaka Habikino Medical Center

    Osaka, Japan, Japan

  • National Hospital Organization Ibarakihigashi National Hospital

    Ibaraki, Osaka, Japan

  • Osaka Metropolitan University Hospital

    Osaka, Osaka, Japan

  • Fukuwa Clinic

    Tokyo, Tokyo, Japan

Poland
  • All-Med Specjalistyczna Opieka Medyczna. Medyczny Instytut Badawczy Marek Jutel

    Wroclaw, Dolnoslaskie Voivodeship, Poland

62 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboVerekitug
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
21 May 2025
Primary completion
30 Sept 2027
Completion
30 Sept 2027
Last update posted
14 May 2026
Registered enrollment
396
Registry id
NCT06966479

Cross-registrations

EU-CTR / CTIS (EudraCT)2024-519469-23-00

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.