Clinical trialNCT06972056RecruitingPhase 4Interventional

Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

SponsorMayo ClinicEnrollment1,335Migraine

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Todd J Schwedt, M.D.
Mayo Clinic
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

36 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Northern Arizona Healthcare
Flagstaff, Arizona, United States
Justin DeLange, D.O.
Recruiting
Mayo Clinic Arizona
Phoenix, Arizona, United States
Juliana VanderPluym, MDTodd Schwedt, MD
Recruiting
Clinical Research Institute
Los Angeles, California, United States
David Kudrow, MD
Recruiting
Keck School of Medicine of Usc
Los Angeles, California, United States
Ana Gjurgevich, NP-CGautum Ganguly, MDHawa Mapara, NP-CSoma Sahai-Srivastava, MD
Recruiting
Desert Physicians Medical Group
Palm Springs, California, United States
Andy Tran, MDGemma Kim, MDJulius Yorac, NPLuanne Carlson, DO
Recruiting
the Neurology Group
Pomona, California, United States
Allegra Danna-Demott, PACBhupat Desai, MDSamer Kebbeh, MD
Recruiting
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Danilee WIlhour, MDJohn Kyle Jenkins, MDMarius Birlea, MDNicole Caunt, MDPauline Sok, NP
Recruiting
Memorial Healthcare
Hollywood, Florida, United States
Brigitte E Farnsworth, MDMaike Blaya, MD
Recruiting
Mayo Clinic Florida
Jacksonville, Florida, United States
Olga Fermo, MD
Recruiting
Apple Med Research
Miami, Florida, United States
Agustin L Latorre, MD
Recruiting
University of Miami
Miami, Florida, United States
Alexandra Cocores, MDLiza Smirnoff, MDTeshamae Monteith, MD
Recruiting
Neuroscience Research Center
Overland Park, Kansas, United States
Mayank Gupta, MD
Recruiting
Clinical Trials of New England
Hyde Park, Massachusetts, United States
Michael Lowney, DOShannon Kriehn, NP
Recruiting
Mayo Clinic
Rochester, Minnesota, United States
Chia-Chun Chiang, MDNarayan Kissoon, MD
Recruiting
Washington University St Louis
St Louis, Missouri, United States
Rachel Darken, MD
Recruiting
Nebraska Medical Center
Omaha, Nebraska, United States
Autumn Nye, APRNBeth Hartman, MDMelissa Donnelly, PA
Recruiting
Advanced Research Institute Reno
Reno, Nevada, United States
Dennis T. Yamamoto, MD
Recruiting
Jfk Neuroscience Institute
Edison, New Jersey, United States
Brian Gerhardstein, MDDipakkumar Pandya, MDEmad Noor, MD
Recruiting
Nuvance Health Institute
Kingston, New York, United States
Janet Tamai, MDJulio Vieira, MDYurida Wolf, LPN
Recruiting
Northwell Health
Manhasset, New York, United States
Noah Rosen, MD
Recruiting
Mt Sinai Icahn School of Medicine
New York, New York, United States
Anna Pace, MDBridget Mueller, MDTanesha Kemble, DNP FNP-BC
Recruiting
Onsite Clinical Solutions Ballantyne
Charlotte, North Carolina, United States
Matthew Acampora, MDSteven Bauer, MD
Recruiting
Onsite Clinical Solutions Mecklenburg
Charlotte, North Carolina, United States
George Raad, MDMichael Amiri, MD
Recruiting
Onsite Clinical Solutions Park Cedar Dr.
Charlotte, North Carolina, United States
Kenneth Ashkin, MDSydney Grey, PA-C
Recruiting
Onsite Clinical Solutions Salisbury
Salisbury, North Carolina, United States
Douglas Shellhorn, MDKishan Maramraj, MD
Recruiting
Wake Forest University Health
Winston-Salem, North Carolina, United States
Barbara Nye, MDRebecca Wells, MD
Recruiting
Ohio State University Wexner Medical Center
Columbus, Ohio, United States
Kevin Weber, MD
Recruiting
Advanced Research Institute
Portland, Oregon, United States
Amal Habib Mohamed Jawad Ali Al Yusuf, MDAnantha Jujjuri, PAJim Bergthold, MDJohn Nguyen, MDWalter Goebel, MD
Recruiting
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Eric Kaiser, MD
Recruiting
Brown University Health
Providence, Rhode Island, United States
Roderick Spears, MD
Recruiting
Vanderbilt Medical Center
Nashville, Tennessee, United States
Francesca Bagnato, MSJoy Derwenskus, MD
Recruiting
Dhr Health Headache Center
McAllen, Texas, United States
Gloria Simms, MD
Recruiting
Advanced Research Institute Ogden
Ogden, Utah, United States
Abbey Coburn, PA-CChristopher L. Davis, DOJonathan N Winkfield, PA-CKhaldoun M Al-Rayess, MDLynae C Sorensen, MSN AP FNP-CMichael D DeLange, MDMichael Woolman, MD
Recruiting
West Virginia University
Morgantown, West Virginia, United States
David Watson, MDHeather Hickman, FNP-BCKristina Lopez, MDLindsey S Keczan, FNP-BCTiffany Lannan, FNP-BC
Recruiting
Marshfield Clinic Research Institute
Marshfield, Wisconsin, United States
Jeff VanWormer, PhDLee Cody, MD
Recruiting
the Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Glen Soloman, MDJames Murtha, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Atogepant →Propranolol →Topiramate →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 9 Jul 2025
Primary completion: 1 Mar 2029
Completion: 1 Dec 2029
Last update posted: 30 Jul 2026
Registered enrollment: 1,335
Registry id: NCT06972056

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.