Clinical trialNCT06985147RecruitingPhase 2Interventional

A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

SponsorDisc Medicine, IncEnrollment60Polycythemia Vera (PV)

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Will Savage, MD PhD
Disc Medicine
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic in Arizona
Phoenix, Arizona, United States
Jeanne Palmer, M.D.
Recruiting
Ucla Health
Los Angeles, California, United States
Gary Schiller, M.D.
Recruiting
Usc Norris Comprehensive Cancer Center
Los Angeles, California, United States
Caitlin O'Neill
Recruiting
Keck Medicine of Usc - Cancer Clinic- Newport Beach
Newport Beach, California, United States
Caitlin O'Neill
Recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Candido Rivera, M.D.
Recruiting
Mayo Clinic in Minnesota
Rochester, Minnesota, United States
Naseema Gangat, M.B.B.S.
Recruiting
Siteman Cancer Center - Washington University St. Louis
St Louis, Missouri, United States
Stephen Oh
Recruiting
Atrium Health - Levine Cancer Center
Charlotte, North Carolina, United States
Anne WoffordMichael Grunwald
Recruiting
Duke University
Durham, North Carolina, United States
Lindsay Rein, MD
Recruiting
Atrium Health Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
Anne Wofford
Recruiting
Cleveland Clinic
Cleveland, Ohio, United States
Aaron Gerds, MD
Recruiting
Ohio State University
Columbus, Ohio, United States
Jennifer E Vaughn, MD
Recruiting
Oregon Health & Science University
Portland, Oregon, United States
Joseph Shatzel
Recruiting
Md Anderson Cancer Center
Houston, Texas, United States
Naveen Pemmaraju, M.D.
Recruiting
University of Washington - Fred Hutchinson Cancer Research Center
Seattle, Washington, United States
Anna Halpern
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

DISC-3405

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 12 Aug 2025
Primary completion: 28 Feb 2027
Completion: 28 Feb 2029
Last update posted: 28 May 2026
Registered enrollment: 60
Registry id: NCT06985147

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.