Clinical trialNCT06998940RecruitingPhase 3Interventional

Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

SponsorSWOG Cancer Research NetworkEnrollment94Locally Advanced Pancreatic AdenocarcinomaMetastatic Pancreatic AdenocarcinomaStage III Pancreatic Cancer AJCC v8Stage IV Pancreatic Cancer AJCC v8Unresectable Pancreatic Adenocarcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of adding panitumumab to standard chemotherapy (with nanoliposomal Irinotecan, leucovorin, and 5-fluorouracil \[5-FU\] or irinotecan, leucovorin, and 5-FU or nab-paclitaxel and gemcitabine) versus standard chemotherapy alone in treating patients with KRAS wild type (WT) pancreatic ductal adenocarcinoma that cannot be removed by sugery (unresectable) or that has spread to nearby tissue or lymph nodes (locally advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic). Panitumumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Chemotherapy drugs, such as nanoliposomal irinotecan, leucovorin, 5-FU, irinotecan, nab-paclitaxel and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Adding panitumumab to standard chemotherapy may be effective in treating patients with unresectable, locally advanced, or metastatic KRAS WT pancreatic ductal adenocarcinoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Rachael A Safyan
SWOG Cancer Research Network
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

274 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Breast Care and Surgery Llc
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Alaska Oncology and Hematology Llc
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Alaska Women'S Cancer Care
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Katmai Oncology Group
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Charles W. Drescher
Recruiting
Cancer Center at Saint Joseph'S
Phoenix, Arizona, United States
Shahzad Siddique
Recruiting
Highlands Oncology Group - Fayetteville
Fayetteville, Arkansas, United States
Joseph T. Beck
Recruiting
Nea Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States
Aleksandar Jankov
Recruiting
Highlands Oncology Group - Rogers
Rogers, Arkansas, United States
Joseph T. Beck
Recruiting
Highlands Oncology Group
Springdale, Arkansas, United States
Joseph T. Beck
Recruiting
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, United States
Shahzad Siddique
Recruiting
Sutter Auburn Faith Hospital
Auburn, California, United States
Uma Suryadevara
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, United States
Uma Suryadevara
Recruiting
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, United States
Uma Suryadevara
Recruiting
Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
Charles W. Drescher
Recruiting
Mills-Peninsula Medical Center
Burlingame, California, United States
Uma Suryadevara
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, United States
Uma Suryadevara
Recruiting
Mercy Cancer Center - Carmichael
Carmichael, California, United States
Shahzad Siddique
Recruiting
Mercy San Juan Medical Center
Carmichael, California, United States
Shahzad Siddique
Recruiting
Eden Hospital Medical Center
Castro Valley, California, United States
Uma Suryadevara
Recruiting
Sutter Davis Hospital
Davis, California, United States
Uma Suryadevara
Recruiting
Mercy Cancer Center - Elk Grove
Elk Grove, California, United States
Shahzad Siddique
Recruiting
Palo Alto Medical Foundation-Fremont
Fremont, California, United States
Uma Suryadevara
Recruiting
Mercy Cancer Center
Merced, California, United States
Shahzad Siddique
Recruiting
Memorial Medical Center
Modesto, California, United States
Uma Suryadevara
Recruiting
Palo Alto Medical Foundation-Camino Division
Mountain View, California, United States
Uma Suryadevara
Recruiting
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, United States
Uma Suryadevara
Recruiting
Providence Queen of the Valley
Napa, California, United States
Charles W. Drescher
Recruiting
Sutter Cancer Research Consortium
Novato, California, United States
Uma Suryadevara
Recruiting
Palo Alto Medical Foundation Health Care
Palo Alto, California, United States
Uma Suryadevara
Recruiting
Mercy Cancer Center - Rocklin
Rocklin, California, United States
Shahzad Siddique
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, United States
Uma Suryadevara
Recruiting
Sutter Roseville Medical Center
Roseville, California, United States
Uma Suryadevara
Recruiting
Mercy Cancer Center - Sacramento
Sacramento, California, United States
Shahzad Siddique
Recruiting
Sutter Medical Center Sacramento
Sacramento, California, United States
Uma Suryadevara
Recruiting
California Pacific Medical Center-Pacific Campus
San Francisco, California, United States
Uma Suryadevara
Recruiting
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, United States
Shahzad Siddique
Recruiting
Mills Health Center
San Mateo, California, United States
Uma Suryadevara
Recruiting
Ridley-Tree Cancer Center
Santa Barbara, California, United States
Uma Suryadevara
Recruiting

234 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Fluorouracil →Gemcitabine →Irinotecan →Irinotecan SucrosofateLeucovorin →Paclitaxel →Panitumumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 13 May 2026
Primary completion: 31 Dec 2029
Completion: 31 Dec 2030
Last update posted: 22 May 2026
Registered enrollment: 94
Registry id: NCT06998940

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.