Clinical trialNCT07020221RecruitingPhase 1/PHASE2Interventional

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

SponsorVerastem, Inc.Enrollment295Colorectal CancerG12D Mutated KRASNon Small Cell Lung CancerPancreatic Ductal AdenocarcinomaSolid Tumor, Adult

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Peninsula and Southeast Oncology
Frankston, Victoria, Australia
Vinod Ganju, MBBS
Recruiting

United States

Cedars-Sinai Medical Center
Los Angeles, California, United States
Arsen Osipov, MD
Recruiting
Johns Hopkins University
Baltimore, Maryland, United States
Nilofer Azad, MD
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
Leon Pappas, MD
Recruiting
University of Michigan
Ann Arbor, Michigan, United States
Vaibhav Sahai, MBBS, MS
Recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Kian-Huat Lim, MD
Recruiting
Laura & Isaac Perlmutter Cancer Center at Nyu Langone
New York, New York, United States
Kristen Spencer, DO
Recruiting
Univ of Pennsylvania, Abramson Cancer Center
Philadelphia, Pennsylvania, United States
Mark O'Hara, MD
Recruiting
Scri Oncology Partners
Nashville, Tennessee, United States
Melissa Johnson, MD
Recruiting
Md Anderson Cancer Center
Houston, Texas, United States
David Hong, MD
Recruiting
Huntsman Cancer Institute
Salt Lake City, Utah, United States
Matthew Gumbleton, MD
Recruiting
University of Virginia
Charlottesville, Virginia, United States
Matthew Reilley, MD
Recruiting
Virginia Cancer Specialists
Fairfax, Virginia, United States
Alexander Spira, MD
Recruiting
Virginia Mason Medical Center
Seattle, Washington, United States
Vincent Picozzi, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin + Pemetrexed + Pembrolizumab →Cetuximab →Gemcitabine →Gemcitabine + Nab-paclitaxel →VS-7375 →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Jun 2025
Primary completion: 31 Dec 2028
Completion: 31 Dec 2028
Last update posted: 22 Apr 2026
Registered enrollment: 295
Registry id: NCT07020221

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.