Clinical trialNCT07022678RecruitingPhase 3Interventional

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

SponsorChildren's Oncology GroupEnrollment556Acute Myeloid LeukemiaRecurrent Acute Myeloid Leukemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of xylitol dental wipes to dental wipes without xylitol for the reduction of bloodstream infection in children with acute myeloid leukemia (AML). Xylitol is a naturally occurring sugar compound found in fruits and vegetables. Xylitol has been shown to limit the growth of bacteria in the mouth, and to reduce cavities, plaque on the teeth, and inflammation of the gums. Treatment for AML includes chemotherapy. Patients receiving chemotherapy for AML have a risk of developing bloodstream infections. Bloodstream infections can make patients very sick, can contribute to delays in treatment, and can even cause death. In AML patients, bacteria or fungus (yeast) can sometimes enter the bloodstream from the mouth. Using xylitol dental wipes may help to reduce bloodstream infections in children being treated for AML.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jennifer J Wilkes
Children's Oncology Group
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

28 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Michael W. Bishop
Recruiting
Valley Children'S Hospital
Madera, California, United States
Ruetima Titapiwatanakun
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Aarati V. Rao
Recruiting
Rocky Mountain Hospital for Children-Presbyterian Saint Luke'S Medical Center
Denver, Colorado, United States
Florence Choo
Recruiting
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Sridhi Patel
Recruiting
Nemours Children'S Clinic-Jacksonville
Jacksonville, Florida, United States
Sridhi Patel
Recruiting
Nemours Children'S Hospital
Orlando, Florida, United States
Sridhi Patel
Recruiting
Nemours Children'S Clinic - Pensacola
Pensacola, Florida, United States
Jeffrey H. Schwartz
Recruiting
Children'S Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States
Tamara P. Miller
Recruiting
Lurie Children'S Hospital-Chicago
Chicago, Illinois, United States
Sara Zarnegar-Lumley
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
James T. Badgett
Recruiting
Norton Children'S Hospital
Louisville, Kentucky, United States
Michael J. Ferguson
Recruiting
Corewell Health Grand Rapids Hospitals - Helen Devos Children'S Hospital
Grand Rapids, Michigan, United States
Kathleen Y. Butler
Recruiting
Bronson Methodist Hospital
Kalamazoo, Michigan, United States
Kathleen Y. Butler
Recruiting
Albany Medical Center
Albany, New York, United States
Lauren R. Weintraub
Recruiting
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States
Alice Lee
Recruiting
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, United States
Duncan S. Stearns
Recruiting
Promedica Toledo Hospital/russell J Ebeid Children'S Hospital
Toledo, Ohio, United States
Jamie L. Dargart
Recruiting
Geisinger Medical Center
Danville, Pennsylvania, United States
Jagadeesh Ramdas
Recruiting
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Rebecca Citrin
Recruiting
Children'S Hospital of Pittsburgh of Upmc
Pittsburgh, Pennsylvania, United States
Jean M. Tersak
Recruiting
East Tennessee Childrens Hospital
Knoxville, Tennessee, United States
Susan E. Spiller
Recruiting
the Children'S Hospital at Tristar Centennial
Nashville, Tennessee, United States
Clinton M. Carroll
Recruiting
Dell Children'S Medical Center of Central Texas
Austin, Texas, United States
Shannon M. Cohn
Recruiting
Medical City Dallas Hospital
Dallas, Texas, United States
Maurizio L. Ghisoli
Recruiting
Ut Southwestern/simmons Cancer Center-Dallas
Dallas, Texas, United States
Gabriella Nguyen
Recruiting
University of Virginia Cancer Center
Charlottesville, Virginia, United States
Brian C. Belyea
Recruiting
Providence Sacred Heart Medical Center and Children'S Hospital
Spokane, Washington, United States
Judy L. Felgenhauer
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cytarabine →Placebo Administration

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 26 May 2026
Primary completion: 15 Jan 2032
Completion: 15 Jan 2033
Last update posted: 16 Jul 2026
Registered enrollment: 556
Registry id: NCT07022678

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.