Clinical trialNCT07100990RecruitingPhase 3Interventional

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

SponsorMayo ClinicEnrollment382MyelitisMyelitis, TransverseOptic Neuritis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

John Chen
Mayo Clinic
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

33 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic Arizona
Scottsdale, Arizona, United States
Dean Wingerchuk, MD
Recruiting
Loma Linda University
Loma Linda, California, United States
Active, not recruiting
University of California, Davis
Sacramento, California, United States
Yin A Liu, MD, PhD
Recruiting
University of Colorado - Anschutz Medical
Aurora, Colorado, United States
Jeffrey Bennett, MD, PhD
Recruiting
Yale University School of Medicine
North Haven, Connecticut, United States
Annalisa Morgan, MD
Recruiting
Mayo Clinic Florida
Jacksonville, Florida, United States
Eric Eggenberger, DO
Recruiting
University of Miami
Miami, Florida, United States
Byron Lam, MD
Recruiting
University of Illinois Chicago
Chicago, Illinois, United States
Peter MacIntosh, MD
Recruiting
Northwestern University
Evanston, Illinois, United States
Shailee Shah, MD
Recruiting
Indiana University
Indianapolis, Indiana, United States
Devin Mackay, MD
Recruiting
Johns Hopkins University
Baltimore, Maryland, United States
Elias Sotirchos, MD
Recruiting
University of Maryland, Baltimore
Baltimore, Maryland, United States
Sarah Fredrich, MD
Recruiting
Medstar Health Research Institute
Columbia, Maryland, United States
Benjamin Osborne, MD
Recruiting
Boston Medical Center
Boston, Massachusetts, United States
Crandall Peeler, MD
Recruiting
Harvard University Massachusetts General Hospital
Boston, Massachusetts, United States
Anastasia Vishnevetsky, MD, MPH
Recruiting
Regents of the University of Michigan
Ann Arbor, Michigan, United States
Lindsey Delott, MD
Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, United States
John Jing-Wei Chen, MD, PhD
Recruiting
University of Mississippi Medical Center
Jackson, Mississippi, United States
Melanie Truong-Le, DO, OD
Recruiting
Columbia University
New York, New York, United States
Kiran Thakur, MD
Recruiting
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Sammita Satyanarayan, MD
Recruiting
Nyu Langone Health
New York, New York, United States
Active, not recruiting
Weill Cornell Medical College
New York, New York, United States
Marc Dinkin, MD
Recruiting
University of North Carolina School of Medicine
Chapel Hill, North Carolina, United States
Active, not recruiting
Duke University Health System
Durham, North Carolina, United States
Nathan Tagg, MD
Recruiting
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Hesham Hesham, MD
Recruiting
Dean Mcgee Eye Institute at University of Oklahoma Health Sciences
Oklahoma City, Oklahoma, United States
Active, not recruiting
Oregon Health & Sciences University
Portland, Oregon, United States
Elizabeth Silbermann, MD
Recruiting
University of Pittsburgh Medical Center, Magee Hospital
Pittsburgh, Pennsylvania, United States
Ingrid Loma-Miller, MD
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee, United States
James Eaton, MDReid Longmuir, MD
Recruiting
Ut Southwestern Medical Center
Dallas, Texas, United States
Peter Sguigna, MD
Recruiting
University of Utah
Salt Lake City, Utah, United States
Stacey Clardy, MD
Recruiting
University of Virginia
Charlottesville, Virginia, United States
Alexandra Simpson, MD
Recruiting
University of Washington
Seattle, Washington, United States
Yujie Wang, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

High-dose corticosteroidsHigh-dose corticosteroids and PLEX

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 11 Jul 2025
Primary completion: 1 Apr 2029
Completion: 30 Apr 2031
Last update posted: 6 Jul 2026
Registered enrollment: 382
Registry id: NCT07100990

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.