Clinical trialNCT07104032RecruitingPhase 3Interventional

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

SponsorOno Pharmaceutical Co., Ltd.Enrollment132Relapsed/Refractory Primary Central Nervous System Lymphoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this clinical trial is to evaluate efficacy and safety of tirabrutinib alone compared with rituximab and temozolomide (R-TMZ) combination therapy in participants with Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Clinical Team
Deciphera Pharmaceuticals, LLC
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

32 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Epworth Healthcare
Melbourne, Victoria, Australia
Costas Yannakou, MD
Recruiting

Czechia

University Hospital Ostrava
Ostrava, Czechia, Czechia
Juraj Ďuraš, MD
Recruiting
University Hospital Královské Vinohrady
Prague, Czechia, Czechia
Heidi Mocikova, MD
Recruiting

France

Hôpitaux de Marseille
Marseille, France, France
Laurence Schenone, MD
Recruiting
Hospital Center University de Montpellier
Montpellier, France, France
Charles Herbaux, MD
Recruiting

Italy

Asst Spedali Civili Di Brescia
Brescia, Italy, Italy
Alessandra Tucci, MD
Recruiting
Irccs Istituto Romagnolo Per Lo Studio Dei Tumori "dino Amadori" - Irst
Meldola, Italy, Italy
Gerardo Musuraca, MD
Recruiting

Spain

Hospital Clínic de Barcelona
Barcelona, Spain, Spain
Pablo Mozas, MD
Recruiting
Hospital Universitario 12 de Octubre
Madrid, Spain, Spain
Antonia Rodríguez Izquierdo, MD
Recruiting

United States

Mayo Clinic Cancer Center
Phoenix, Arizona, United States
Mazie Tsang, MD
Recruiting
Honorhealth Cancer Center
Scottsdale, Arizona, United States
Amir Azadi, MD
Recruiting
Providence Medical Foundation
Fullerton, California, United States
Jose Carrillo, MD
Recruiting
Uc Irvine Health
Orange, California, United States
Daniela Bota, MD, PhD
Recruiting
Yale Cancer Center
New Haven, Connecticut, United States
Sylvia Kurz, MD
Recruiting
John Hopkins University
Washington D.C., District of Columbia, United States
Solmaz Sahebjam, MD
Recruiting
University of Florida Gainesville
Gainesville, Florida, United States
Ashley Ghiaseddin, MD
Recruiting
Mayo Clinic Cancer Center
Jacksonville, Florida, United States
Han Tun, MD
Recruiting
University of Maryland
Baltimore, Maryland, United States
Seung Lee, MD
Recruiting
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Ka-Wai Grace Ho, MD
Recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Lakshmi Nayak, MD
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
Tracy Batchelor, MD
Recruiting
Mayo Clinic Cancer Center
Rochester, Minnesota, United States
Patrick Johnston, MD, PhD
Recruiting
Hackensack University Medical Center
Hackensack, New Jersey, United States
Andrew Ip, MD
Recruiting
Atlantic Health Overlook Medical Center
Summit, New Jersey, United States
Robert Aiken, MD
Recruiting
Columbia University Irving Medical Center
New York, New York, United States
Aya Haggiagi, MD
Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Christian Grommes, MD
Recruiting
Nyu Langone Health
New York, New York, United States
J Ricardo McFaline Figueroa, MD
Recruiting
Duke University Medical Center
Durham, North Carolina, United States
Katherine Peters, MD, PhD
Recruiting
Providence Neurological Specialties West
Portland, Oregon, United States
Prakash Ambady, MD
Recruiting
Penn State Health Milton S Hershey Medical Center
Hershey, Pennsylvania, United States
Dawit Aregawi, MD
Recruiting
Upmc Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Jan Drappatz, MD
Recruiting
Rhode Island Hospital
Providence, Rhode Island, United States
Thomas Ollila, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Rituximab →Temozolomide →Tirabrutinib

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 12 Jun 2026
Primary completion: 31 Dec 2027
Completion: 31 Dec 2029
Last update posted: 18 Aug 2026
Registered enrollment: 132
Registry id: NCT07104032

Cross-registrations

EU-CTR / CTIS (EudraCT)2025-523389-26-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.